Isolation and Characterization of Polybrominated Diphenyl Ethers as Inhibitors of Microtubule Assembly from the Marine Sponge Phyllospongia dendyi Collected at Palau

Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3-11) from the marine sponge Phyllospongia dendyi collected from Palau. The structures were assigned on the basis of their spectral data. Compounds 3, 7, and 10 showed in...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.472-474
Main Authors: LIU, Hongwei, NAMIKOSHI, Michio, MEGURO, Shiori, NAGAI, Hiroshi, KOBAYASHI, Hisayoshi, YAO, Xinsheng
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Division - drug effects
Demospongiae
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Ethers - chemistry
Ethers - isolation & purification
Ethers - pharmacology
General pharmacology
Inhibitory Concentration 50
Marine
Medical sciences
Microtubules - drug effects
Microtubules - metabolism
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oceans and Seas
Oocytes - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phyllospongia dendyi
Polybrominated Biphenyls - chemistry
Polybrominated Biphenyls - isolation & purification
Polybrominated Biphenyls - pharmacology
Porifera - chemistry
Starfish - drug effects
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Summary:Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3-11) from the marine sponge Phyllospongia dendyi collected from Palau. The structures were assigned on the basis of their spectral data. Compounds 3, 7, and 10 showed inhibitory activities to the assembly of microtubule proteins (IC(50): 29.6, 33.5, and 20.9 microM, respectively) and to the meiotic maturation of starfish oocytes (IC(50): 3.6, 4.2, and 4.2 microM, respectively), while 1, 2, 4-6, 8, 9, and 11 were not active at 100 microM. Two phenolic hydroxyls are required for their bioactivities.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0304621