Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction

It has been suggested that increased platelet activation increases the risk of acute myocardial infarction (AMI) in patients with depression. Selective serotonin reuptake inhibitors (SSRIs) may attenuate platelet activation by serotonin depletion in platelets. Observational studies have shown discre...

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Bibliographic Details
Published in:Drug safety 2004-01, Vol.27 (14), p.1157-1165
Main Authors: SCHLIENFER, Raymond G, FISCHER, Lorenz M, JICK, Hershel, MEIER, Christoph R
Format: Article
Language:English
Subjects:
Age Distribution
Aged
Aged, 80 and over
Antidepressive Agents - adverse effects
Antidepressive Agents - therapeutic use
Biological and medical sciences
Case-Control Studies
Databases, Factual
Depression - drug therapy
Drug toxicity and drugs side effects treatment
Family Practice
Female
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - chemically induced
Myocardial Infarction - epidemiology
Pharmacology. Drug treatments
Risk Factors
Serotonin Uptake Inhibitors - adverse effects
Serotonin Uptake Inhibitors - therapeutic use
Sex Distribution
Toxicity: cardiovascular system
United Kingdom - epidemiology
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Summary:It has been suggested that increased platelet activation increases the risk of acute myocardial infarction (AMI) in patients with depression. Selective serotonin reuptake inhibitors (SSRIs) may attenuate platelet activation by serotonin depletion in platelets. Observational studies have shown discrepant results of AMI risk associated with the use of SSRIs. The aim of this study was to evaluate the association of exposure to different groups of antidepressants, including SSRIs, and the risk of AMI. The study also assessed in more detail the influence of timing of the exposure to antidepressants in a general adult population (
ISSN:0114-5916
DOI:10.2165/00002018-200427140-00006