Real-time concentration monitoring in microfluidic system via plasmonic nanocrescent arrays

In this work, on-chip bio/chemical sensor was reported based on localized surface plasmon resonance of nanocrescent patterns fabricated via electron beam lithography. The nanocrescent arrays with different dimensional features exhibited controllable plasmonic properties in accordance with the simula...

Full description

Saved in:
Bibliographic Details
Published in:Biosensors & bioelectronics 2016-03, Vol.77, p.385-392
Main Authors: Zhou, Bingpu, Xiao, Xiao, Liu, Ting, Gao, Yibo, Huang, Yingzhou, Wen, Weijia
Format: Article
Language:English
Subjects:
Arrays
Biopolymers - analysis
Biosensor
Chemical sensors
Computer Systems
Dynamics
Equipment Design
Equipment Failure Analysis
Flow Injection Analysis - instrumentation
Gold - chemistry
Lab-On-A-Chip Devices
Metal Nanoparticles - chemistry
Microfluidics
Monitoring
Nanocrescent
Nanostructure
Plasmonics
Real time
Surface plasmon resonance
Surface Plasmon Resonance - instrumentation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, on-chip bio/chemical sensor was reported based on localized surface plasmon resonance of nanocrescent patterns fabricated via electron beam lithography. The nanocrescent arrays with different dimensional features exhibited controllable plasmonic properties in accordance with the simulation results based on the finite-difference time-domain model. The highest refractive index sensitivity of the fabricated samples was achieved to be ~699.2nm/RIU with a figure of merit of ~3.1 when the two opposite crescents own a gap of ~43.3nm. Such obtained plasmonic sensor was further integrated into the microfluidic system which can simply control the specific analyte concentrations via tuning the flow rate ratios between two injecting microstreams. Our method has successfully demonstrated the capability of the nanocrescent patterns as on-chip plasmonic bio/chemical sensor for real-time monitoring of dynamic concentrations in the microchannel. •Well tunable plasmonic properties of Au nanocrescent arrays were obtained via precisely controlling the dimensional features.•Highest refractive index sensitivity of the fabricated samples was achieved to be ~699.2nm/RIU with a figure of merit of ~3.1.•The plasmonic biosensor was integrated into microfluidic concentration gradient generator and capable of real-time monitoring the dynamic concentration variation in the microchannel.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2015.09.054