Cytotoxic Metabolites Produced by the Endophytic Fungus Aspergillus clavatus

A new spiro azaphilone derivative, aspergillusone C (1), and a new cadinane-type sesquiterpenoid, aspergillusone D (2), together with a known azaphilone, felinone A (3), were isolated from the endophytic fungus Aspergillus clavatus. The structures of the new compounds were elucidated by NMR spectros...

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Bibliographic Details
Published in:Chemistry letters 2015, Vol.44 (8), p.1148-1149
Main Authors: Wang, Jiaming, Bai, Gang, Liu, Yihan, Wang, Hongbin, Li, Yu, Yin, Wanqiang, Wang, Yonglu, Lu, Fuping
Format: Article
Language:English
Subjects:
Aspergillus
Biotechnology
Circularity
Derivatives
Dichroism
Fungi
Metabolites
NMR spectroscopy
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Summary:A new spiro azaphilone derivative, aspergillusone C (1), and a new cadinane-type sesquiterpenoid, aspergillusone D (2), together with a known azaphilone, felinone A (3), were isolated from the endophytic fungus Aspergillus clavatus. The structures of the new compounds were elucidated by NMR spectroscopy and electron circular dichroism data. Compound 2 exhibited detectable cytotoxic activity against two cell lines (MCF-7 and A549), with IC50 values of 5.9 and 0.2 µM, respectively, in the MTT assay.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.150417