Surface Functionalization of Protein Crystals with Carbohydrate Using Site-selective Bioconjugation

A crystalline solid protein assembly was functionalized with Lewis X (LeX) carbohydrates via site-selective bioconjugation of cysteine residues. An antibody can bind to the surface of modified crystals through antigen–antibody interactions. The surface modification of protein crystals would provide...

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Bibliographic Details
Published in:Chemistry letters 2015-01, Vol.44 (1), p.29-31
Main Authors: Abe, Satoshi, Tokura, Yu, Pal, Rita, Komura, Naoko, Imamura, Akihiro, Matsumoto, Kaori, Ijiri, Hiroshi, Sanghamitra, Nusrat J M, Tabe, Hiroyasu, Ando, Hiromune, Kiso, Makoto, Mori, Hajime, Kitagawa, Susumu, Ueno, Takafumi
Format: Article
Language:English
Subjects:
Antibodies
Assembly
Carbohydrates
Crystal structure
Crystals
Cysteine
Proteins
Residues
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Summary:A crystalline solid protein assembly was functionalized with Lewis X (LeX) carbohydrates via site-selective bioconjugation of cysteine residues. An antibody can bind to the surface of modified crystals through antigen–antibody interactions. The surface modification of protein crystals would provide attractive materials for applications involving extracellular matrices, biosolid catalysis, and drug delivery systems.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.140865