A Simple and Efficient Procedure for the One-pot Three-component Synthesis of Spiro[indoline-3,9′-tetrazolo[5,1-b]quinazoline]-2,8′(5′H)-dione in PEG–H2O Medium

Novel spiro[indoline-3,9′-tetrazolo[5,1-b]quinazoline]-2,8′(5′H)-dione derivatives have been synthesized by the three-component reaction of isatin, 5-amino-1H-tetrazole, and 5,5-dimethylcyclohexane-1,3-dione in PEG–H2O medium catalyzed by p-TSA. This protocol provides a simple one-step procedure wit...

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Bibliographic Details
Published in:Chemistry letters 2014-08, Vol.43 (8), p.1239-1241
Main Authors: Shen, Minggui, Wang, Juan, Shang, Shibin, Song, Zhanqian
Format: Article
Language:English
Subjects:
Chemical reactions
Derivatives
Synthesis
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Summary:Novel spiro[indoline-3,9′-tetrazolo[5,1-b]quinazoline]-2,8′(5′H)-dione derivatives have been synthesized by the three-component reaction of isatin, 5-amino-1H-tetrazole, and 5,5-dimethylcyclohexane-1,3-dione in PEG–H2O medium catalyzed by p-TSA. This protocol provides a simple one-step procedure with the advantages of easy work-up, mild reaction conditions, and environmental benignity.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.140186