Use of diffusion tensor imaging in assessing superficial myometrial invasion by endometrial carcinoma: a preliminary study

Background Magnetic resonance imaging (MRI) remains the standard modality for local staging of gynecological malignancies, but it has several limitations, especially when differentiating a cancer limited to the endometrium from a cancer invading the superficial myometrium. Purpose To explore 1.5 T d...

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Bibliographic Details
Published in:Acta radiologica (1987) 2015-10, Vol.56 (10), p.1273-1280
Main Authors: Zhang, Longmin, Liu, Ailian, Zhang, Ting, Song, Qingwei, Wei, Qiang, Wang, Heqing
Format: Article
Language:English
Subjects:
Aged
Anisotropy
Cancer
Diagnosis, Differential
Diffusion
Diffusion Tensor Imaging - methods
Endometrial Neoplasms - pathology
Female
Fibers
Humans
Image Interpretation, Computer-Assisted
Imaging
Infiltration
Mathematical analysis
Middle Aged
Myometrium - pathology
Neoplasm Invasiveness - pathology
Retrospective Studies
Sensitivity and Specificity
Tensors
Uterine Neoplasms - pathology
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Summary:Background Magnetic resonance imaging (MRI) remains the standard modality for local staging of gynecological malignancies, but it has several limitations, especially when differentiating a cancer limited to the endometrium from a cancer invading the superficial myometrium. Purpose To explore 1.5 T diffusion tensor imaging (DTI) in assessing superficial myometrial infiltration by endometrial carcinoma. Material and Methods We analyzed the sensitivity of apparent diffusion coefficient (ADC) versus fractional anisotropy (FA) in diagnosing superficial myometrial infiltration compared to DCE-MRI and T2-weighted imaging (T2WI) in 35 patients with endometrial cancer. For each patient, T2WI-DWI fusion images were generated, and five regions of interest (ROIs) were placed on corresponding DTI images. ADC and FA were calculated, and fiber tractography (FT) images for each level were obtained. ADC and FA values for the five ROIs were compared. Results In distinguishing cancerous versus non-cancerous areas within superficial myometrium, median ADC values were significantly lower (1.16 vs. 1.48, respectively; P 
ISSN:0284-1851
1600-0455
DOI:10.1177/0284185114552293