Fabrication of broad area optical nanostructures for high throughput chemical sensing

In this work, we implement an optical resonant sensor with high throughput capabilities to act as chemical or biosensor. We optimized the diffraction grating structures by FDTD simulations. Based on this study, we produced dielectric diffractive gratings in 1cm2 areas by laser interference lithograp...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2013-10, Vol.187, p.356-362
Main Authors: Rodríguez-Franco, P., Arriola, A., Darwish, N., Jaramillo, J.J., Keshmiri, H., Tavera, T., Olaizola, S.M., Moreno, M.
Format: Article
Language:English
Subjects:
Biosensors
Chemical sensors
crystals
Diffraction gratings
Finite-difference time-domain (FDTD) methods
Fluorescence labeling
Gratings (spectra)
High throughput
Label-free biosensors
Laser interference lithography (LIL)
Lithography
Mass production
nanomaterials
Nanostructure
Optical resonant sensors
Refractive index
Refractivity
wavelengths
White light
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Summary:In this work, we implement an optical resonant sensor with high throughput capabilities to act as chemical or biosensor. We optimized the diffraction grating structures by FDTD simulations. Based on this study, we produced dielectric diffractive gratings in 1cm2 areas by laser interference lithography (LIL) and interrogated them with white light. The reflected single wavelength shifted with changes of the external medium's refractive index (RI), resolving variations of 7.3×10−5 refractive index units (RIU). To exploit the broad active areas fabricated, we developed a custom instrument to acquire spatial maps of the resonance. We called the technique broad area resonance scan (BARS) and used it to characterize the geometric and material uniformity of the surfaces. We suggest this as an in situ practice to characterize photonic crystals and also as a method to scan highly parallelized analysis on a single chip in real time. In addition to a refractometric label-free application, we demonstrated a fluorescent-based measurement with the same readout and found state of the art sensitivities. Thus, the multimethod platform presented is able to double prove an assay with a single experiment in addition to its ability to screen large numbers of interactions using low volume of reagents.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2012.12.039