An implantable smart magnetic nanofiber device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release

• Published in: Acta biomaterialia 2016-02, Vol.31, p.122-133
• Main Authors: Sasikala, Arathyram Ramachandra Kurup, Unnithan, Afeesh Rajan, Yun, Yeo-Heung, Park, Chan Hee, Kim, Cheol Sang
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Biocompatibility; Biocompatible Materials - chemistry; Bivalvia; Bortezomib; Bortezomib - administration & dosage; Bortezomib - chemistry; Cancer; Catechols - chemistry; Cell Line, Tumor; Chemotherapy; Devices; Dopamine - chemistry; Drug Delivery Systems; Drug Liberation; Endoscopes; Endoscopy - methods; Ferric Compounds - chemistry; Hydrogen-Ion Concentration; Hyperthermia; Hyperthermia, Induced - methods; Lactic Acid - chemistry; Magnetic fields; Magnetic nanofiber; Magnetics; Magnetite Nanoparticles - chemistry; Medical devices; Mice; Mussel-inspired; Nanofibers - chemistry; Nanostructure; Neoplasms - drug therapy; NIH 3T3 Cells; Polyglycolic Acid - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Thermogravimetry
• ISSN: 1742-7061; 1878-7568
• DOI: 10.1016/j.actbio.2015.12.015

[Display omitted] The study describes the design and synthesis of an implantable smart magnetic nanofiber device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release. This device is achieved using a two-component smart nanofiber matrix from monodisperse iron oxide nanoparticles (IONPs) as well as bortezomib (BTZ), a chemotherapeutic drug. The IONP-incorporated nanofiber matrix was developed by electrospinning a biocompatible and bioresorbable polymer, poly (d,l-lactide-co-glycolide) (PLGA), and tumor-triggered anticancer drug delivery is realized by exploiting mussel-inspired surface functionalization using 2-(3,4-dihydroxyphenyl)ethylamine (dopamine) to conjugate the borate-containing BTZ anticancer drug through a catechol metal binding in a pH-sensitive manner. Thus, an implantable smart magnetic nanofiber device can be exploited to both apply hyperthermia with an alternating magnetic field (AMF) and to achieve cancer cell-specific drug release to enable synergistic cancer therapy. These results confirm that the BTZ-loaded mussel-inspired magnetic nanofiber matrix (BTZ-MMNF) is highly beneficial not only due to the higher therapeutic efficacy and low toxicity towards normal cells but also, as a result of the availability of magnetic nanoparticles for repeated hyperthermia application and tumor-triggered controlled drug release. The current work report on the design and development of a smart nanoplatform responsive to a magnetic field to administer both hyperthermia and pH-dependent anticancer drug release for the synergistic anticancer treatment. The iron oxide nanoparticles (IONPs) incorporated nanofiber matrix was developed by electrospinning a biocompatible polymer, poly (d,l-lactide-co-glycolide) (PLGA), and tumor-triggered anticancer drug delivery is realized by surface functionalization using 2-(3,4-dihydroxyphenyl)ethylamine (dopamine) to conjugate the boratecontaining anticancer drug bortezomib through a catechol metal binding in a pH-sensitive manner. This implantable magnetic nanofiber device can be exploited to apply hyperthermia with an alternating magnetic field and to achieve cancer cell-specific drug release to enable synergistic cancer therapy, which results in an improvement in both quality of life and patient compliance.