Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds

The synthetic utilities of the diazo and diazonium groups are matched only by their reputation for explosive decomposition. Continuous processing technology offers new opportunities to make and use these versatile intermediates at a range of scales with improved safety over traditional batch process...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2015-02, Vol.21 (6), p.2298-2308
Main Authors: Deadman, Benjamin J., Collins, Stuart G., Maguire, Anita R.
Format: Article
Language:English
Subjects:
Batch processes
Catalysis
Chemistry
Continuous flow
Continuous processing
Decomposition
diazocarbonyls
diazomethane
Diazomethane - chemical synthesis
Diazomethane - chemistry
Diazonium Compounds - chemical synthesis
Diazonium Compounds - chemistry
diazonium ions
Explosions
flow chemistry
Hazardous
Rhodium - chemistry
Safety
State of the art
Utilities
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthetic utilities of the diazo and diazonium groups are matched only by their reputation for explosive decomposition. Continuous processing technology offers new opportunities to make and use these versatile intermediates at a range of scales with improved safety over traditional batch processes. In this minireview, the state of the art in the continuous flow processing of reactive diazo and diazonium species is discussed. Safety first: The synthetic utilities of the diazo and diazonium groups are matched only by their reputation for explosive decomposition. Continuous processing technology offers new opportunities to make and use these versatile intermediates with improved safety. This Minireview discusses the state of the art in flow chemistry involving these reactive species.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201404348