LipidGO: database for lipid-related GO terms and applications

Lipid, an essential class of biomolecules, is receiving increasing attention in the research community, especially with the development of analytical technique like mass spectrometry. Gene Ontology (GO) is the de facto standard function annotation scheme for gene products. Identification of both exp...

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Bibliographic Details
Published in:Bioinformatics 2014-04, Vol.30 (7), p.1043-1044
Main Authors: Fan, Mengyuan, Low, Hong Sang, Zhou, Hufeng, Wenk, Markus R, Wong, Limsoon
Format: Article
Language:English
Subjects:
Construction
Databases, Genetic
Gene Expression
Genes
Lipid Metabolism
Lipids
Lipids - analysis
Lists
Mathematical models
Proteins - genetics
Proteins - metabolism
Receiving
Searching
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Summary:Lipid, an essential class of biomolecules, is receiving increasing attention in the research community, especially with the development of analytical technique like mass spectrometry. Gene Ontology (GO) is the de facto standard function annotation scheme for gene products. Identification of both explicit and implicit lipid-related GO terms will help lipid research in many ways, e.g. assigning lipid function in protein function prediction. We have constructed a Web site 'LipidGO' that facilitates browsing and searching lipid-related GO terms. An expandable hierarchical GO tree is constructed that allows users to find lipid-related GO terms easily. To support large-scale analysis, a user is able to upload a list of gene products or a list of GO terms to find out which of them is lipid related. Finally, we demonstrate the usefulness of 'LipidGO' by two applications: (i) identifying lipid-related gene products in model organisms and (ii) discovering potential novel lipid-related molecular functions LipidGO is available at http://compbio.ddns.comp.nus.edu.sg/%7elipidgo/index.php.
ISSN:1367-4803
1367-4811
1460-2059
DOI:10.1093/bioinformatics/btt689