Double-integrating-sphere system at the National Institute of Standards and Technology in support of measurement standards for the determination of optical properties of tissue-mimicking phantoms

There is a need for a common reference point that will allow for the comparison of the optical properties of tissue-mimicking phantoms. After a brief review of the methods that have been used to measure the phantoms for a contextual backdrop to our approach, this paper reports on the establishment o...

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Bibliographic Details
Published in:Journal of biomedical optics 2015-12, Vol.20 (12), p.121310-121310
Main Authors: Lemaillet, Paul, Bouchard, Jean-Pierre, Hwang, Jeeseong, Allen, David W
Format: Article
Language:English
Subjects:
Algorithms
Anisotropy
Calibration
Diagnostic Imaging - standards
Estimates
Humans
Lasers
Optical properties
Optics and Photonics - standards
Phantoms, Imaging - standards
Platforms
Polarization
Refractometry
Reproducibility of Results
Scattering coefficients
Scattering, Radiation
Uncertainty
United States
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Summary:There is a need for a common reference point that will allow for the comparison of the optical properties of tissue-mimicking phantoms. After a brief review of the methods that have been used to measure the phantoms for a contextual backdrop to our approach, this paper reports on the establishment of a standardized double-integrating-sphere platform to measure absorption and reduced scattering coefficients of tissue-mimicking biomedical phantoms. The platform implements a user-friendly graphical user interface in which variations of experimental configurations and model-based analysis are implemented to compute the coefficients based on a modified inverse adding-doubling algorithm allowing a complete uncertainty evaluation. Repeatability and validation of the measurement results of solid phantoms are demonstrated for three samples of different thicknesses, d=5.08  mm, 7.09 mm, and 9.92 mm, with an absolute error estimate of 4.0% to 5.0% for the absorption coefficient and 11% to 12% for the reduced scattering coefficient (k=2). The results are in accordance with those provided by the manufacturer. Measurements with different polarization angles of the incident light are also presented, and the resulting optical properties were determined to be equivalent within the estimated uncertainties.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.20.12.121310