Dysprosium-containing layered double hydroxides nanoparticles intercalated with biologically active species as an approach for theranostic systems

•LDH structure including dysprosium was prepared by co-precipitation.•LDH was capable to produce contrast in the T1 mode of MRI.•LDH were intercalated with folate, ibuprofen and gallate ions. A layered double hydroxide structure including dysprosium cations was prepared by co-precipitation. The nano...

Full description

Saved in:
Bibliographic Details
Published in:Materials science & engineering. B, Solid-state materials for advanced technology Solid-state materials for advanced technology, 2016-01, Vol.203, p.7-12
Main Authors: Arratia-Quijada, Jenny, Sánchez Jiménez, Cecilia, Gurinov, Andrey, Pérez Centeno, Armando, Ceja Andrade, Israel, Carbajal Arízaga, Gregorio Guadalupe
Format: Article
Language:English
Subjects:
Carrier
Cations
Contrast agent
Coprecipitation
Diseases
Drug
Dysprosium
Hydroxides
Medical services
MRI
Nanoparticles
Nanostructure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•LDH structure including dysprosium was prepared by co-precipitation.•LDH was capable to produce contrast in the T1 mode of MRI.•LDH were intercalated with folate, ibuprofen and gallate ions. A layered double hydroxide structure including dysprosium cations was prepared by co-precipitation. The nanoparticles showed a linear relationship with the reciprocal relaxation spin-lattice (T1) time of water protons which is reflected as contrast in aqueous suspensions analyzed by magnetic resonance imaging. The interlayer space of dysprosium containing LDH was successfully intercalated with folate, ibuprofen and gallate ions, which are key molecules for recognition of some cancer cells and treatment of diseases. The paramagnetic property of the dysprosium-containing LDH detected in this work beside the ability to transport drugs open up the opportunity to design theranostic materials in a single crystal phase with nanometric dimensions.
ISSN:0921-5107
1873-4944
DOI:10.1016/j.mseb.2015.10.004