Simultaneous determination of captopril and hydrochlorothiazide on boron-doped diamond electrode by batch injection analysis with multiple pulse amperometric detection

•Fast simultaneous determination of captopril and hydrochlorothiazide.•Minimal sample manipulation (dissolution and dilution in electrolyte).•Simultaneous determination with a single injection step (100 injections h−1).•Rapid detection of the presence of electroactive interferents (fast screening te...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2015-06, Vol.212, p.411-418
Main Authors: Gimenes, Denise Tofanello, Marra, Mariana Cardoso, de Freitas, Jhonys Machado, Abarza Muñoz, Rodrigo Alejandro, Richter, Eduardo Mathias
Format: Article
Language:English
Subjects:
Actuators
Batch injection analysis
Boron-doped diamond
Captopril
Confidence intervals
Diamonds
Electrical measurements
Electrodes
Electrolytes
Hydrochlorothiazide
Multiple pulse amperometry
Screening
Screening test
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Summary:•Fast simultaneous determination of captopril and hydrochlorothiazide.•Minimal sample manipulation (dissolution and dilution in electrolyte).•Simultaneous determination with a single injection step (100 injections h−1).•Rapid detection of the presence of electroactive interferents (fast screening test). This work describes a new, simple, and fast electrochemical method for simultaneous determination of captopril (CAP) and hydrochlorothiazide (HCT) using a boron-doped diamond (BDD) electrode associated with batch-injection analysis with multiple-pulse amperometric (BIA–MPA) detection. A sequence of potential pulses was selected in such a way that HCT was selectively detected at +1.4V/50ms and both (HCT+CAP), were detected at +1.8V/50ms. CAP was quantified without interference of HCT by subtracting the currents detected at +1.8V and +1.4V (using a correction factor). The proposed BIA method requires minimal sample manipulation (dissolution and dilution in electrolyte) and the simultaneous determination is achieved with a single injection step of 150μL of a sample solution (100injectionsh−1). The results obtained with the BIA method were compared to those obtained by capillary electrophoresis and similar results were obtained (at 95% of confidence level). A simple and rapid test for detecting the presence or absence of electroactive interferents was also proposed (fast screening test).
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2015.01.132