Retrospective survey to evaluate the safety and efficacy of Japanese botulinum antitoxin therapy in Japan

Japanese botulinum antitoxins have been used for more than 50 years; however, their safety and therapeutic efficacy are not clear. In order to analyze the available data on botulinum antitoxin therapy in Japan, we surveyed published reports about botulism cases in which botulinum antitoxins were use...

Full description

Saved in:
Bibliographic Details
Published in:Toxicon (Oxford) 2016-02, Vol.110, p.12-18
Main Authors: Mottate, Keita, Yokote, Hiroyuki, Mori, Shigemi, Horita, Akira, Miyatsu, Yoshinobu, Torii, Yasushi, Kozaki, Shunji, Iwaki, Masaaki, Takahashi, Motohide, Ginnaga, Akihiro
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Botulinum Antitoxin - adverse effects
Botulinum Antitoxin - therapeutic use
Botulism
Botulism - drug therapy
Botulism - mortality
Botulism - physiopathology
Child
Clostridium botulinum
Effectiveness
Fatal
Fatalities
Fatality rate
Female
Health Care Surveys
Humans
Japan - epidemiology
Male
Middle Aged
Patients
Public Health Informatics
Retrospective Studies
Retrospective survey
Safety
Severity of Illness Index
Side effect
Side effects
Survival Analysis
Therapy
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Japanese botulinum antitoxins have been used for more than 50 years; however, their safety and therapeutic efficacy are not clear. In order to analyze the available data on botulinum antitoxin therapy in Japan, we surveyed published reports about botulism cases in which botulinum antitoxins were used, and retrospectively analyzed the safety and efficacy of the therapy. A total of 134 patients administered botulinum antitoxins were identified from published reports. Two cases of side effects (1.5%) were detected after antitoxin administration, both not fatal. The fatality rate was 9.4%, and more than 70% of the patients showed improvement in their symptoms and better clinical conditions than those not treated with antitoxins. These data suggest that the therapy with Japanese antitoxins is safe and highly effective. •A total of 134 patients administered botulinum antitoxins were detected in Japan.•Side effects of antitoxins were reported in 2 patients, but both were not fatal.•The fatality rate was 9.4% among 127 patients properly administered antitoxins.•More than 70% of the patients showed improvement in their symptoms after treatment.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2015.11.010