Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-02, Vol.138, p.110-116
• Main Authors: Yu, Deng-Guang, Yang, Chen, Jin, Miao, Williams, Gareth R., Zou, Hua, Wang, Xia, Annie Bligh, S.W.
• Format: Article
• Language: English
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Cellulose - analogs & derivatives; Cellulose - chemistry; Coating; Complement; Drug Carriers - chemistry; Drug delivery systems; Drug Liberation; Electrochemical Techniques - methods; Electrospinning; Fibers; Janus fibers; Ketoprofen; Ketoprofen - chemistry; Ketoprofen - pharmacokinetics; Microscopy, Electron, Scanning; Nano drug delivery systems; Nanofibers - chemistry; Nanofibers - ultrastructure; Polytetrafluoroethylene - chemistry; Polytetrafluoroethylenes; Povidone - chemistry; Reproducibility of Results; Side-by-side electrospinning; Spinnerets; Structural nanocomposites; Technology, Pharmaceutical - methods; Teflon-coated spinneret; Tunable release rates
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2015.11.055

[Display omitted] •A facile and useful side-by-side electrospinning process.•A new Teflon-coated side-by-side spinneret.•Janus fibers consisting of drug in hydrophilic polymer and insoluble polymer.•Biphasic drug release profiles with a tunable release rate at the second phase.•Clear mechanisms for both the preparation and controlled-release applications. A family of medicated Janus fibers that provides highly tunable biphasic drug release was fabricated using a side-by-side electrospinning process employing a Teflon-coated parallel spinneret. The coated spinneret facilitated the formation of a Janus Taylor cone and in turn high quality integrated Janus structures, which could not be reliably obtained without the Teflon coating. The fibers prepared had one side consisting of polyvinylpyrrolidone (PVP) K60 and ketoprofen, and the other of ethyl cellulose (EC) and ketoprofen. To modulate and tune drug release, PVP K10 was doped into the EC side in some cases. The fibers were linear and had flat morphologies with an indent in the center. They provide biphasic drug release, with the PVP K60 side dissolving very rapidly to deliver a loading dose of the active ingredient, and the EC side resulting in sustained release of the remaining ketoprofen. The addition of PVP K10 to the EC side was able to accelerate the second stage of release; variation in the dopant amount permitted the release rate and extent this phase to be precisely tuned. These results offer the potential to rationally design systems with highly controllable drug release profiles, which can complement natural biological rhythms and deliver maximum therapeutic effects.