Chiral Iminophosphoranes-An Emerging Class of Superbase Organocatalysts

Chiral Brønsted base catalysis is a fascinating and highly explored field of research. For many years catalysts based on chincona alkaloid chiral scaffolds have constituted privileged systems widely employed in numerous base‐promoted organic transformations. Recently, a novel group of chiral base ca...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2015-07, Vol.21 (29), p.10268-10277
Main Authors: Krawczyk, Henryk, Dzięgielewski, Marek, Deredas, Dariusz, Albrecht, Anna, Albrecht, Łukasz
Format: Article
Language:English
Subjects:
Alkaloids
asymmetric catalysis
Asymmetry
bifunctional catalysis
Brønsted base catalysis
Catalysis
Catalysts
Chemistry
Design engineering
iminophosphoranes
organosuperbases
Receiving
Synthesis
Transformations
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chiral Brønsted base catalysis is a fascinating and highly explored field of research. For many years catalysts based on chincona alkaloid chiral scaffolds have constituted privileged systems widely employed in numerous base‐promoted organic transformations. Recently, a novel group of chiral base catalysts has been successfully introduced. The application of organosuperbases, namely cyclopropenimines, guanidines, and iminophosphoranes, as chiral catalysts is receiving increasing attention. The aim of this Concept article is to summarize recent progress in the field of chiral iminophosphorane superbase organocatalysis. Catalysts design, different approaches to their synthesis, and applications in asymmetric synthesis are outlined and discussed in detail. All about that base! Recently, chiral iminophosphoranes (see scheme) have emerged as a new class of organosuperbase catalysts. This Concept article summarizes recent progress in this field of research. Catalyst design, different approaches to synthesis, and applications in asymmetric synthesis are outlined and discussed in detail.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201500481