Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process

A new microfluidic assembly method for semiconductor‐based biosensors using 3D‐printing technologies was proposed for a rapid and cost‐efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D‐printer in just a few hours and assembled on a light‐addressable potent...

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Bibliographic Details
Published in:Physica status solidi. A, Applications and materials science Applications and materials science, 2015-06, Vol.212 (6), p.1347-1352
Main Authors: Takenaga, S., Schneider, B., Erbay, E., Biselli, M., Schnitzler, Th, Schöning, M. J., Wagner, T.
Format: Article
Language:English
Subjects:
3D printing
Biocompatibility
Biosensors
Biotechnology
Cell culture
Cell growth
Chinese hamster ovary cell
Chips
Devices
fetal calf serum
lab-on-chip
light-addressable potentiometric sensor
Materials science
Medical devices
Microfluidics
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Summary:A new microfluidic assembly method for semiconductor‐based biosensors using 3D‐printing technologies was proposed for a rapid and cost‐efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D‐printer in just a few hours and assembled on a light‐addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics‐based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D‐printed chips. Furthermore, an optimal cell culturing within microfluidics‐based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
ISSN:1862-6300
1862-6319
DOI:10.1002/pssa.201532053