DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis

DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent no...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2016-05, Vol.473 (4), p.1163-1169
Main Authors: Tian, Qiu-Hong, Zhang, Mei-Fang, Luo, Rong-Guang, Fu, Jia, He, Cong, Hu, Gang, Zeng, Jing-Sheng
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
China - epidemiology
DEAD-box RNA Helicases - genetics
DEAD-box RNA Helicases - metabolism
DHX33
Disease-Free Survival
Female
Gene Expression Regulation, Neoplastic
Hepatocellular carcinoma
Humans
Immunohistochemistry
Liver Neoplasms - diagnosis
Liver Neoplasms - metabolism
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Prevalence
Prognosis
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Survival Rate
Up-Regulation
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Summary:DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent nontumorous tissues. In a cohort of 520 patients, DHX33 expression in HCC was closely associated with tumor size (P = 0.007), serum AFP level (P = 0.011), and tumor capsule (P = 0.030). Kaplan–Meier analysis indicated high DHX33 expression was correlated with worse overall and disease-free survival, and higher recurrence rate. The prognostic value of DHX33 was further confirmed by stratified survival analysis. Multivariate analysis revealed DHX33 as an independent prognostic factor for poor overall survival (Hazard Ratio = 1.772, 95% confident interval: 1.451–2.165, P 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2016.04.033