Loading…
DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis
DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent no...
Saved in:
| Published in: | Biochemical and biophysical research communications 2016-05, Vol.473 (4), p.1163-1169 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c405t-7456855a3de17077251c508a5dd059d5c37973bb13c49de5024c9c5b94b715063 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c405t-7456855a3de17077251c508a5dd059d5c37973bb13c49de5024c9c5b94b715063 |
| container_end_page | 1169 |
| container_issue | 4 |
| container_start_page | 1163 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 473 |
| creator | Tian, Qiu-Hong Zhang, Mei-Fang Luo, Rong-Guang Fu, Jia He, Cong Hu, Gang Zeng, Jing-Sheng |
| description | DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent nontumorous tissues. In a cohort of 520 patients, DHX33 expression in HCC was closely associated with tumor size (P = 0.007), serum AFP level (P = 0.011), and tumor capsule (P = 0.030). Kaplan–Meier analysis indicated high DHX33 expression was correlated with worse overall and disease-free survival, and higher recurrence rate. The prognostic value of DHX33 was further confirmed by stratified survival analysis. Multivariate analysis revealed DHX33 as an independent prognostic factor for poor overall survival (Hazard Ratio = 1.772, 95% confident interval: 1.451–2.165, P |
| doi_str_mv | 10.1016/j.bbrc.2016.04.033 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1786517062</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X16305289</els_id><sourcerecordid>1786517062</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-7456855a3de17077251c508a5dd059d5c37973bb13c49de5024c9c5b94b715063</originalsourceid><addsrcrecordid>eNp9kE9PwzAMxSMEYmPwBTigHrm0OE3SrhIXNP4MaRIXQLtFaeJBpq0pSYvg25NqgyMnW_Lz8_OPkHMKGQVaXK2zuvY6y2OfAc-AsQMyplBBmlPgh2QMAEWaV3Q5IichrAEo5UV1TEZ5CSWjBRuT19v5krEEv1qPIVjXJDYkttEeVUATu-QdW9U5jZtNv1E-0cpr27itSlQzzI3VqsOQtM75pPXurXHBhlNytFKbgGf7OiEv93fPs3m6eHp4nN0sUs1BdGnJRTEVQjGDNEYqc0G1gKkSxoCojNCsrEpW15RpXhkUkHNdaVFXvC6pgIJNyOXON17-6DF0cmvDkFU16PogaTktRLQu8ijNd1LtXQgeV7L1dqv8t6QgB55yLQeecuApgcvIMy5d7P37eovmb-UXYBRc7wQYv_y06GXQFhuNxnrUnTTO_uf_AxD8hbY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1786517062</pqid></control><display><type>article</type><title>DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis</title><source>Elsevier</source><creator>Tian, Qiu-Hong ; Zhang, Mei-Fang ; Luo, Rong-Guang ; Fu, Jia ; He, Cong ; Hu, Gang ; Zeng, Jing-Sheng</creator><creatorcontrib>Tian, Qiu-Hong ; Zhang, Mei-Fang ; Luo, Rong-Guang ; Fu, Jia ; He, Cong ; Hu, Gang ; Zeng, Jing-Sheng</creatorcontrib><description>DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent nontumorous tissues. In a cohort of 520 patients, DHX33 expression in HCC was closely associated with tumor size (P = 0.007), serum AFP level (P = 0.011), and tumor capsule (P = 0.030). Kaplan–Meier analysis indicated high DHX33 expression was correlated with worse overall and disease-free survival, and higher recurrence rate. The prognostic value of DHX33 was further confirmed by stratified survival analysis. Multivariate analysis revealed DHX33 as an independent prognostic factor for poor overall survival (Hazard Ratio = 1.772, 95% confident interval: 1.451–2.165, P < 0.0001). Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease.
•DHX33 expression was increased in HCC tissues.•High DHX33 expression was correlated with poor outcomes in a cohort of 520 patients with HCC.•Multivariate analysis indicates DHX33 as an independent biomarker for unfavorable prognosis.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2016.04.033</identifier><identifier>PMID: 27073163</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; China - epidemiology ; DEAD-box RNA Helicases - genetics ; DEAD-box RNA Helicases - metabolism ; DHX33 ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Hepatocellular carcinoma ; Humans ; Immunohistochemistry ; Liver Neoplasms - diagnosis ; Liver Neoplasms - metabolism ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Prevalence ; Prognosis ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Survival Rate ; Up-Regulation</subject><ispartof>Biochemical and biophysical research communications, 2016-05, Vol.473 (4), p.1163-1169</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-7456855a3de17077251c508a5dd059d5c37973bb13c49de5024c9c5b94b715063</citedby><cites>FETCH-LOGICAL-c405t-7456855a3de17077251c508a5dd059d5c37973bb13c49de5024c9c5b94b715063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27073163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Qiu-Hong</creatorcontrib><creatorcontrib>Zhang, Mei-Fang</creatorcontrib><creatorcontrib>Luo, Rong-Guang</creatorcontrib><creatorcontrib>Fu, Jia</creatorcontrib><creatorcontrib>He, Cong</creatorcontrib><creatorcontrib>Hu, Gang</creatorcontrib><creatorcontrib>Zeng, Jing-Sheng</creatorcontrib><title>DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent nontumorous tissues. In a cohort of 520 patients, DHX33 expression in HCC was closely associated with tumor size (P = 0.007), serum AFP level (P = 0.011), and tumor capsule (P = 0.030). Kaplan–Meier analysis indicated high DHX33 expression was correlated with worse overall and disease-free survival, and higher recurrence rate. The prognostic value of DHX33 was further confirmed by stratified survival analysis. Multivariate analysis revealed DHX33 as an independent prognostic factor for poor overall survival (Hazard Ratio = 1.772, 95% confident interval: 1.451–2.165, P < 0.0001). Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease.
•DHX33 expression was increased in HCC tissues.•High DHX33 expression was correlated with poor outcomes in a cohort of 520 patients with HCC.•Multivariate analysis indicates DHX33 as an independent biomarker for unfavorable prognosis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>China - epidemiology</subject><subject>DEAD-box RNA Helicases - genetics</subject><subject>DEAD-box RNA Helicases - metabolism</subject><subject>DHX33</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Survival Rate</subject><subject>Up-Regulation</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kE9PwzAMxSMEYmPwBTigHrm0OE3SrhIXNP4MaRIXQLtFaeJBpq0pSYvg25NqgyMnW_Lz8_OPkHMKGQVaXK2zuvY6y2OfAc-AsQMyplBBmlPgh2QMAEWaV3Q5IichrAEo5UV1TEZ5CSWjBRuT19v5krEEv1qPIVjXJDYkttEeVUATu-QdW9U5jZtNv1E-0cpr27itSlQzzI3VqsOQtM75pPXurXHBhlNytFKbgGf7OiEv93fPs3m6eHp4nN0sUs1BdGnJRTEVQjGDNEYqc0G1gKkSxoCojNCsrEpW15RpXhkUkHNdaVFXvC6pgIJNyOXON17-6DF0cmvDkFU16PogaTktRLQu8ijNd1LtXQgeV7L1dqv8t6QgB55yLQeecuApgcvIMy5d7P37eovmb-UXYBRc7wQYv_y06GXQFhuNxnrUnTTO_uf_AxD8hbY</recordid><startdate>20160513</startdate><enddate>20160513</enddate><creator>Tian, Qiu-Hong</creator><creator>Zhang, Mei-Fang</creator><creator>Luo, Rong-Guang</creator><creator>Fu, Jia</creator><creator>He, Cong</creator><creator>Hu, Gang</creator><creator>Zeng, Jing-Sheng</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160513</creationdate><title>DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis</title><author>Tian, Qiu-Hong ; Zhang, Mei-Fang ; Luo, Rong-Guang ; Fu, Jia ; He, Cong ; Hu, Gang ; Zeng, Jing-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-7456855a3de17077251c508a5dd059d5c37973bb13c49de5024c9c5b94b715063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>China - epidemiology</topic><topic>DEAD-box RNA Helicases - genetics</topic><topic>DEAD-box RNA Helicases - metabolism</topic><topic>DHX33</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Survival Rate</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Qiu-Hong</creatorcontrib><creatorcontrib>Zhang, Mei-Fang</creatorcontrib><creatorcontrib>Luo, Rong-Guang</creatorcontrib><creatorcontrib>Fu, Jia</creatorcontrib><creatorcontrib>He, Cong</creatorcontrib><creatorcontrib>Hu, Gang</creatorcontrib><creatorcontrib>Zeng, Jing-Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Qiu-Hong</au><au>Zhang, Mei-Fang</au><au>Luo, Rong-Guang</au><au>Fu, Jia</au><au>He, Cong</au><au>Hu, Gang</au><au>Zeng, Jing-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2016-05-13</date><risdate>2016</risdate><volume>473</volume><issue>4</issue><spage>1163</spage><epage>1169</epage><pages>1163-1169</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>DEAH-box helicase 33 (DHX33) has been implicated in ribosome biogenesis, mRNA translation and inflammation. However, the role of DHX33 in human cancer is rarely studied. Here, we showed that DHX33 expression was significantly increased in hepatocellular carcinoma (HCC), compared with the adjacent nontumorous tissues. In a cohort of 520 patients, DHX33 expression in HCC was closely associated with tumor size (P = 0.007), serum AFP level (P = 0.011), and tumor capsule (P = 0.030). Kaplan–Meier analysis indicated high DHX33 expression was correlated with worse overall and disease-free survival, and higher recurrence rate. The prognostic value of DHX33 was further confirmed by stratified survival analysis. Multivariate analysis revealed DHX33 as an independent prognostic factor for poor overall survival (Hazard Ratio = 1.772, 95% confident interval: 1.451–2.165, P < 0.0001). Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease.
•DHX33 expression was increased in HCC tissues.•High DHX33 expression was correlated with poor outcomes in a cohort of 520 patients with HCC.•Multivariate analysis indicates DHX33 as an independent biomarker for unfavorable prognosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27073163</pmid><doi>10.1016/j.bbrc.2016.04.033</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2016-05, Vol.473 (4), p.1163-1169 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1786517062 |
| source | Elsevier |
| subjects | Aged Aged, 80 and over Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology China - epidemiology DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism DHX33 Disease-Free Survival Female Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Humans Immunohistochemistry Liver Neoplasms - diagnosis Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - pathology Male Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Prevalence Prognosis Reproducibility of Results Risk Factors Sensitivity and Specificity Survival Rate Up-Regulation |
| title | DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T01%3A47%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=DHX33%20expression%20is%20increased%20in%20hepatocellular%20carcinoma%20and%20indicates%20poor%20prognosis&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Tian,%20Qiu-Hong&rft.date=2016-05-13&rft.volume=473&rft.issue=4&rft.spage=1163&rft.epage=1169&rft.pages=1163-1169&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2016.04.033&rft_dat=%3Cproquest_cross%3E1786517062%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-7456855a3de17077251c508a5dd059d5c37973bb13c49de5024c9c5b94b715063%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1786517062&rft_id=info:pmid/27073163&rfr_iscdi=true |