Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone

The bioavailability of the reduced form of coenzyme Q10 (ubiquinol) was compared to oxidized coenzyme Q10 (ubiquinone) with identical soft gel capsule excipients by measuring steady state plasma coenzyme Q10 (CoQ10) levels in 12 healthy volunteers. After baseline levels of ubiquinol, ubiquinone, tot...

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Bibliographic Details
Published in:Clinical pharmacology in drug development 2014-01, Vol.3 (1), p.13-17
Main Authors: Langsjoen, Peter H., Langsjoen, Alena M.
Format: Article
Language:English
Subjects:
coenzyme Q10
plasma level
supplementation
ubiquinol
ubiquinone
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Summary:The bioavailability of the reduced form of coenzyme Q10 (ubiquinol) was compared to oxidized coenzyme Q10 (ubiquinone) with identical soft gel capsule excipients by measuring steady state plasma coenzyme Q10 (CoQ10) levels in 12 healthy volunteers. After baseline levels of ubiquinol, ubiquinone, total CoQ10, α‐tocopherol, and total cholesterol were obtained, follow‐up lab work was performed after 4 weeks of 200 mg/day of ubiquinone, after 4 weeks washout, and after 4 weeks of 200 mg/day of ubiquinol. Plasma total CoQ10 increased from 0.9 to 2.5 µg/mL (P 
ISSN:2160-763X
2160-7648
DOI:10.1002/cpdd.73