Mechanism of Dissolution-Induced Nanoparticle Formation from a Copovidone-Based Amorphous Solid Dispersion

Amorphous solid dispersions (ASDs) have been increasingly used to maximize human exposures from poorly soluble drug candidates. One well-studied advantage of ASDs is the increased amorphous drug solubility compared to crystalline forms. This provides more rapid dissolution rates. An additional advan...

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Bibliographic Details
Published in:Molecular pharmaceutics 2016-05, Vol.13 (5), p.1467-1481
Main Authors: Harmon, Paul, Galipeau, Kendra, Xu, Wei, Brown, Chad, Wuelfing, W. Peter
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical - methods
Hydrophobic and Hydrophilic Interactions
Nanoparticles - chemistry
Particle Size
Pyrrolidines - chemistry
Solubility
Solutions - chemistry
Surface-Active Agents - chemistry
Vinyl Compounds - chemistry
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Summary:Amorphous solid dispersions (ASDs) have been increasingly used to maximize human exposures from poorly soluble drug candidates. One well-studied advantage of ASDs is the increased amorphous drug solubility compared to crystalline forms. This provides more rapid dissolution rates. An additional advantage of ASDs is that the dissolution process of the ASD particle may also rapidly transform much of the drug present in the ASD particle to small (
ISSN:1543-8384
1543-8392
DOI:10.1021/acs.molpharmaceut.5b00863