Analysis of expression of PTEN/PI3K pathway and programmed cell death ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)

•PI3K pathway and PD-L1 are frequently expressed in MPM.•PD-L1 is a negative prognostic factor.•There is no association between PI3K pathway and PD-L1 in MPM. Malignant pleural mesothelioma (MPM) frequently express elevated AKT/mTOR activity. Previous reports in gliomas, colon, breast and prostate c...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-06, Vol.96, p.1-6
Main Authors: Cedrés, S., Ponce-Aix, S., Pardo-Aranda, N., Navarro-Mendivil, A., Martinez-Marti, A., Zugazagoitia, J., Sansano, I., Montoro, M.A., Enguita, A., Felip, E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
B7-H1 Antigen - biosynthesis
B7-H1 Antigen - metabolism
Biomarkers, Tumor - metabolism
Female
Forkhead Box Protein O3 - metabolism
Humans
Lung Neoplasms - enzymology
Lung Neoplasms - immunology
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Malignant pleural mesothelioma
Mesothelioma - enzymology
Mesothelioma - immunology
Mesothelioma - metabolism
Mesothelioma - pathology
Mesothelioma, Malignant
Middle Aged
PD-L1
Phosphatidylinositol 3-Kinases - biosynthesis
Phosphatidylinositol 3-Kinases - metabolism
PI3 K
Pleural Neoplasms - enzymology
Pleural Neoplasms - immunology
Pleural Neoplasms - metabolism
Pleural Neoplasms - pathology
Prognosis
Prognostic factor
PTEN Phosphohydrolase - biosynthesis
PTEN Phosphohydrolase - metabolism
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Summary:•PI3K pathway and PD-L1 are frequently expressed in MPM.•PD-L1 is a negative prognostic factor.•There is no association between PI3K pathway and PD-L1 in MPM. Malignant pleural mesothelioma (MPM) frequently express elevated AKT/mTOR activity. Previous reports in gliomas, colon, breast and prostate cancer suggest that PTEN/PI3K pathway may be important for the induction of PD-L1 expression. This study explored the expression of PTEN/PI3K pathway and PD-L1 in MPM and its relationship with the patient́s prognosis Twenty seven consecutive MPM patients were reviewed. Formalin-fixed, paraffin-embedded tissue biopsies were used for immunohistochemical analysis of PTEN/PI3K pathway and PD-L1 Expression of PTEN, mTOR, pAKT, p4EBP1, peif4E, pS6 and FOXO3a was found in 88.5%, 92.3%, 78.3%, 38.5%, 100%, 52.2% and 100% of tumors and PD-L1 in 23%. We found a significant correlation between pAKT, FOXO3a and PD-L1 expression and longer overall survival (p 
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.03.001