Cellular responses to DNA damage

Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or a...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2001-01, Vol.41 (1), p.367-401
Main Authors: Norbury, C J, Hickson, I D
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - drug effects
Cell Cycle - physiology
Cell Death - drug effects
Cell Death - physiology
DNA - chemistry
DNA - drug effects
DNA Damage - physiology
DNA Repair - drug effects
Humans
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or as air- and water-borne agents. Endogenous damaging agents include methylating species and the reactive oxygen species that arise during respiration. Although diverse responses are elicited in cells following DNA damage, this review focuses on three aspects: DNA repair mechanisms, cell cycle checkpoints, and apoptosis. Because the areas of nucleotide excision repair and mismatch repair have been covered extensively in recent reviews, we restrict our coverage of the DNA repair field to base excision repair and DNA double-strand break repair.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev.pharmtox.41.1.367