Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2005-04, Vol.68 (4), p.537-539
• Main Authors: Subeki, Matsuura, H, Takahashi, K, Yamasaki, M, Yamato, O, Maede, Y, Katakura, K, Kobayashi, S, Trimurningsih, Chairul
• Format: Article
• Language: English
• Subjects: Animals; antiprotozoal agents; Babesia - drug effects; Babesia gibsoni; Biological and medical sciences; carbohydrate structure; Gallic Acid - analogs & derivatives; Gallic Acid - chemistry; Gallic Acid - isolation & purification; Gallic Acid - pharmacology; Gas Chromatography-Mass Spectrometry; General pharmacology; glucogallin; glucose; Glucose - analogs & derivatives; Glucose - chemistry; Glucose - isolation & purification; Glucose - pharmacology; Glucosides - chemistry; Glucosides - isolation & purification; Glucosides - pharmacology; Indonesia; Inhibitory Concentration 50; Medical sciences; medicinal plants; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phyllanthus - chemistry; Phyllanthus niruri; phytochemicals; plant extracts; Plants, Medicinal - chemistry; Plasmodium falciparum; Plasmodium falciparum - drug effects; spectral analysis; stereochemistry
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0497245

Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro. The known compounds beta-glucogallin (2), quercetin 3-O-beta-d-glucopyranosyl-(2-->1)-O-beta-d-xylopyranoside (3), beta-sitosterol, and gallic acid were also isolated. Structures of these compounds were elucidated on the basis of their chemical and spectroscopic data.