Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing death of the motor neurons. Proteotoxicity caused by TDP-43 protein is an important aspect of ALS pathogenesis, with TDP-43 being the main constituent of the aggregates found in patients. We have previously tested the effect...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry 2016-05, Vol.64 (17), p.3338-3344
Main Authors: Aaron, Catherine, Beaudry, Gabrielle, Parker, J. Alex, Therrien, Martine
Format: Article
Language:English
Subjects:
Acer - chemistry
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - prevention & control
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Disease Models, Animal
DNA-Binding Proteins - toxicity
Gas Chromatography-Mass Spectrometry
Plant Extracts - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing death of the motor neurons. Proteotoxicity caused by TDP-43 protein is an important aspect of ALS pathogenesis, with TDP-43 being the main constituent of the aggregates found in patients. We have previously tested the effect of different sugars on the proteotoxicity caused by the expression of mutant TDP-43 in Caenorhabditis elegans. Here we tested maple syrup, a natural compound containing many active molecules including sugars and phenols, for neuroprotective activity. Maple syrup decreased several age-dependent phenotypes caused by the expression of TDP-43A315T in C. elegans motor neurons and requires the FOXO transcription factor DAF-16 to be effective.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.5b05432