Maternal diet during pregnancy and lactation and cow’s milk allergy in offspring

Background/Objectives: Diet during pregnancy and lactation may have a role in the development of allergic diseases. There are few human studies on the topic, especially focusing on food allergies. We sought to study the associations between maternal diet during pregnancy and lactation and cow’s milk...

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Bibliographic Details
Published in:European journal of clinical nutrition 2016-05, Vol.70 (5), p.554-559
Main Authors: Tuokkola, J, Luukkainen, P, Tapanainen, H, Kaila, M, Vaarala, O, Kenward, M G, Virta, L J, Veijola, R, Simell, O, Ilonen, J, Knip, M, Virtanen, S M
Format: Article
Language:English
Subjects:
692/499
Adult
Allergic diseases
Allergic rhinitis
Allergies
Animals
Antigens
Asthma
Breastfeeding & lactation
Child, Preschool
Clinical Nutrition
Confidence intervals
Cord blood
Cow's milk
Diabetes mellitus (insulin dependent)
Diet
Diet - adverse effects
Diet Surveys
Epidemiology
Female
Fetal Blood - immunology
Finland
Food
Food allergies
Food allergy
Food and nutrition
Food consumption
Health aspects
Histocompatibility antigen HLA
Humans
Immunoglobulin A
Immunoglobulin A - analysis
Infant
Infants
Internal Medicine
Lactation
Lactation - physiology
Leukocytes
Logistic Models
Male
Maternal Nutritional Physiological Phenomena - physiology
Medicine
Medicine & Public Health
Metabolic Diseases
Milk
Milk - adverse effects
Milk Hypersensitivity - etiology
Milk Hypersensitivity - prevention & control
Milk products
Offspring
original-article
Pregnancy
Pregnant women
Prenatal Exposure Delayed Effects - etiology
Public Health
Rhinitis
Risk factors
Statistical analysis
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Summary:Background/Objectives: Diet during pregnancy and lactation may have a role in the development of allergic diseases. There are few human studies on the topic, especially focusing on food allergies. We sought to study the associations between maternal diet during pregnancy and lactation and cow’s milk allergy (CMA) in offspring. Subjects/Methods: A population-based birth cohort with human leukocyte antigen-conferred susceptibility to type 1 diabetes was recruited in Finland between 1997 and 2004 ( n =6288). Maternal diet during pregnancy and lactation was assessed by a validated, 181-item semi-quantitative food frequency questionnaire. Register-based information on diagnosed CMA was obtained from the Social Insurance Institution and completed with parental reports. The associations between maternal food consumption and CMA were assessed using logistic regression, comparing the highest and the lowest quarters to the middle half of consumption. Results: Consumption of milk products in the highest quarter during pregnancy was associated with a lower risk of CMA in offspring (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.37–0.86; P
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2015.223