Intrinsic and extrinsic mechanical properties related to the differentiation of mesenchymal stem cells

Diverse intrinsic and extrinsic mechanical factors have a strong influence on the regulation of stem cell fate. In this work, we examined recent literature on the effects of mechanical environments on stem cells, especially on differentiation of mesenchymal stem cells (MSCs). We provide a brief revi...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2016-05, Vol.473 (3), p.752-757
Main Authors: Lee, Jin-Ho, Park, Hun-Kuk, Kim, Kyung Sook
Format: Article
Language:English
Subjects:
Adipocytes - cytology
Cell Differentiation
Cell Lineage
Differentiation
Dimethylpolysiloxanes - chemistry
Elasticity
Humans
mechanical properties
Mechanical property
Mechanotransduction
Mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
nanomaterials
Nanostructures - chemistry
Osteoblasts - cytology
Osteogenesis
Pressure
stem cells
Stress, Mechanical
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Summary:Diverse intrinsic and extrinsic mechanical factors have a strong influence on the regulation of stem cell fate. In this work, we examined recent literature on the effects of mechanical environments on stem cells, especially on differentiation of mesenchymal stem cells (MSCs). We provide a brief review of intrinsic mechanical properties of single MSC and examined the correlation between the intrinsic mechanical property of MSC and the differentiation ability. The effects of extrinsic mechanical factors relevant to the differentiation of MSCs were considered separately. The effect of nanostructure and elasticity of the matrix on the differentiation of MSCs were summarized. Finally, we consider how the extrinsic mechanical properties transfer to MSCs and then how the effects on the intrinsic mechanical properties affect stem cell differentiation. •Mechanical properties relevant to the differentiation of MSCs were summarized.•Effects of intrinsic and extrinsic mechanical factors were considered separately.•Stiff cells well differentiate to osteoblasts while soft cells to adipocytes.•Differentiation of MSCs influenced by nano-structure and elasticity of matrix.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2015.09.081