Glutathione S-transferase K1 genotype and overweight status in schizophrenia patients: A pilot study

Abstract Elevated oxidative stress in mitochondria and mitochondrial dysfunction are associated with weight gain in schizophrenia (SCZ) patients. Glutathione S-transferase kappa 1 (GSTK1) protects cells against exogenous and endogenous oxidative stress in the mitochondria. This exploratory study inv...

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Bibliographic Details
Published in:Psychiatry research 2016-05, Vol.239, p.190-195
Main Authors: Oniki, Kentaro, Kamihashi, Ryoko, Tomita, Tetsu, Ishioka, Masamichi, Yoshimori, Yuki, Osaki, Natsumi, Tsuchimine, Shoko, Sugawara, Norio, Kajiwara, Ayami, Morita, Kazunori, Miyata, Keishi, Otake, Koji, Nakagawa, Kazuko, Ogata, Yasuhiro, Saruwatari, Junji, Yasui-Furukori, Norio
Format: Article
Language:English
Subjects:
Adult
Female
Genotype
Glutathione S-transferase kappa 1
Glutathione Transferase - genetics
Humans
Leukocytes, Mononuclear
Male
Middle Aged
Mitochondria
mRNA
Overweight
Overweight - genetics
Pilot Projects
Polymorphism, Genetic
Psychiatry
Schizophrenia
Schizophrenia - genetics
Sex Factors
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Summary:Abstract Elevated oxidative stress in mitochondria and mitochondrial dysfunction are associated with weight gain in schizophrenia (SCZ) patients. Glutathione S-transferase kappa 1 (GSTK1) protects cells against exogenous and endogenous oxidative stress in the mitochondria. This exploratory study investigated the possible effects of a common GSTK1 polymorphism (rs1917760, G-1308T) on the risk for overweight status among 329 SCZ patients and 305 age- and gender-matched controls and on the GSTK1 mRNA level in peripheral blood mononuclear cells among 14 SCZ patients. The GSTK1 T/T genotype was associated with having a higher BMI value among SCZ male patients, whereas this genotype tended to be associated with a lower BMI value among female patients. Conversely, these associations were not observed among the controls. The GSTK1 T/T genotype was associated with decreased GSTK1 mRNA level among SCZ patients. The GSTK1 T/T genotype may be a novel risk factor for the prediction of overweight status in SCZ male patients, although the results of this pilot study should be verified by a larger study.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2016.03.025