Platelet serotonin concentration and depressive symptoms in patients with schizophrenia

Abstract Depressive symptoms seem to be frequent in schizophrenia, but so far they have received less attention than other symptom domains. Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. The objectives of this study were to investigat...

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Bibliographic Details
Published in:Psychiatry research 2016-05, Vol.239, p.105-110
Main Authors: Peitl, Vjekoslav, Vidrih, Branka, Karlović, Zoran, Getaldić, Biserka, Peitl, Milena, Karlović, Dalibor
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Blood platelets
Blood Platelets - metabolism
Cross-Sectional Studies
Depression
Depression - blood
Depression - diagnosis
Depression - psychology
Female
Humans
Male
Middle Aged
Prevalence
Psychiatric Status Rating Scales
Psychiatry
Schizophrenia
Schizophrenia - blood
Schizophrenia - diagnosis
Schizophrenic Psychology
Serotonin
Serotonin - blood
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Summary:Abstract Depressive symptoms seem to be frequent in schizophrenia, but so far they have received less attention than other symptom domains. Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. The objectives of this study were to investigate platelet serotonin concentrations in schizophrenic patients with and without depressive symptoms, and to investigate the association between platelet serotonin concentrations and symptoms of schizophrenia, mostly depressive symptoms. A total of 364 patients were included in the study, 237 of which had significant depressive symptoms. Significant depressive symptoms were defined by the cut-off score of 7 or more on Calgary Depression Rating Scale (CDSS). Platelet serotonin concentrations were assessed by the enzyme-linked immunosorbent assay (ELISA). Prevalence of depression in patients with schizophrenia was 65.1%. Schizophrenic patients with depressive symptoms showed lower platelet serotonin concentrations (mean±SD; 490.6±401.2) compared to schizophrenic patients without depressive symptoms (mean±SD; 660.9±471.5). An inverse correlation was established between platelet serotonin concentration and depressive symptoms, with more severe symptoms being associated with lower platelet serotonin concentrations. Depressive symptoms in schizophrenic patients may be associated with reduced concentrations of platelet serotonin.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2016.03.006