Junctional proteins of the blood-brain barrier: New insights into function and dysfunction

The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of...

Full description

Saved in:
Bibliographic Details
Published in:Tissue barriers 2016-01, Vol.4 (1), p.e1154641-e1154641
Main Authors: Stamatovic, Svetlana M, Johnson, Allison M, Keep, Richard F, Andjelkovic, Anuska V
Format: Article
Language:English
Subjects:
actin cytoskeleton
adherens junction
Animals
Blood-Brain Barrier - metabolism
brain endothelial cells
Capillary Permeability
cell-cell contact
gap junction
Humans
Mutation
Protein Processing, Post-Translational
Review
tight junction
Tight Junction Proteins - chemistry
Tight Junction Proteins - genetics
Tight Junction Proteins - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c468t-81aa23c293f8def82463add101920c0e5b2d57a5ccbfb7a91eff5163b5410e363
cites cdi_FETCH-LOGICAL-c468t-81aa23c293f8def82463add101920c0e5b2d57a5ccbfb7a91eff5163b5410e363
container_end_page e1154641
container_issue 1
container_start_page e1154641
container_title Tissue barriers
container_volume 4
creator Stamatovic, Svetlana M
Johnson, Allison M
Keep, Richard F
Andjelkovic, Anuska V
description The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability. However, such alterations are also involved in remodeling the brain endothelial cell surface and regulating brain endothelial cell phenotype. This review summarizes the characteristics of brain endothelial tight, adherens and gap junctions and highlights structural and functional alterations in junctional proteins that may contribute to BBB dysfunction.
doi_str_mv 10.1080/21688370.2016.1154641
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1787096929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1787096929</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-81aa23c293f8def82463add101920c0e5b2d57a5ccbfb7a91eff5163b5410e363</originalsourceid><addsrcrecordid>eNp9kU1vGyEQhlGVqonc_IRWHHtZh2FZYHuoEkVtPhS1l_bSC2L5iKnW4AJO5H_ftfyh5hIuzDDvvDPiQegDkDkQSS4ocClbQeaUAJ8DdIwzeIPOtu_NtnByjDk9Reel_CHTkZQTwd6hUyqAAaPiDP2-X0dTQ4p6xKucqgux4ORxXTg8jCnZZsg6RDzonIPLn_F394wnTXhc1DIFNWG_d8A6Wmw35ZC_R2-9Hos7398z9Ovb15_Xt83Dj5u766uHxjAuayNBa9oa2rdeWuclZbzV1gKBnhJDXDdQ2wndGTP4QegenPcd8HboGBDX8naGvux8V-th6axxsWY9qlUOS503KumgXlZiWKjH9KTY9DtMwGTwaW-Q09-1K1UtQzFuHHV0aV0UCClIz_tpxRnqdlKTUynZ-eMYIGqLRh3QqC0atUcz9X38f8dj1wHEJLjcCUL0KS_1c8qjVVVvxpR91tGEotrXZ_wDksufqg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1787096929</pqid></control><display><type>article</type><title>Junctional proteins of the blood-brain barrier: New insights into function and dysfunction</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><source>PubMed Central</source><creator>Stamatovic, Svetlana M ; Johnson, Allison M ; Keep, Richard F ; Andjelkovic, Anuska V</creator><creatorcontrib>Stamatovic, Svetlana M ; Johnson, Allison M ; Keep, Richard F ; Andjelkovic, Anuska V</creatorcontrib><description>The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability. However, such alterations are also involved in remodeling the brain endothelial cell surface and regulating brain endothelial cell phenotype. This review summarizes the characteristics of brain endothelial tight, adherens and gap junctions and highlights structural and functional alterations in junctional proteins that may contribute to BBB dysfunction.</description><identifier>ISSN: 2168-8362</identifier><identifier>ISSN: 2168-8370</identifier><identifier>EISSN: 2168-8370</identifier><identifier>DOI: 10.1080/21688370.2016.1154641</identifier><identifier>PMID: 27141427</identifier><language>eng</language><publisher>United States: Taylor &amp; Francis</publisher><subject>actin cytoskeleton ; adherens junction ; Animals ; Blood-Brain Barrier - metabolism ; brain endothelial cells ; Capillary Permeability ; cell-cell contact ; gap junction ; Humans ; Mutation ; Protein Processing, Post-Translational ; Review ; tight junction ; Tight Junction Proteins - chemistry ; Tight Junction Proteins - genetics ; Tight Junction Proteins - metabolism</subject><ispartof>Tissue barriers, 2016-01, Vol.4 (1), p.e1154641-e1154641</ispartof><rights>2016 Taylor &amp; Francis Group, LLC 2016</rights><rights>2016 Taylor &amp; Francis Group, LLC 2016 Taylor &amp; Francis Group, LLC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-81aa23c293f8def82463add101920c0e5b2d57a5ccbfb7a91eff5163b5410e363</citedby><cites>FETCH-LOGICAL-c468t-81aa23c293f8def82463add101920c0e5b2d57a5ccbfb7a91eff5163b5410e363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836471/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836471/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27141427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stamatovic, Svetlana M</creatorcontrib><creatorcontrib>Johnson, Allison M</creatorcontrib><creatorcontrib>Keep, Richard F</creatorcontrib><creatorcontrib>Andjelkovic, Anuska V</creatorcontrib><title>Junctional proteins of the blood-brain barrier: New insights into function and dysfunction</title><title>Tissue barriers</title><addtitle>Tissue Barriers</addtitle><description>The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability. However, such alterations are also involved in remodeling the brain endothelial cell surface and regulating brain endothelial cell phenotype. This review summarizes the characteristics of brain endothelial tight, adherens and gap junctions and highlights structural and functional alterations in junctional proteins that may contribute to BBB dysfunction.</description><subject>actin cytoskeleton</subject><subject>adherens junction</subject><subject>Animals</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>brain endothelial cells</subject><subject>Capillary Permeability</subject><subject>cell-cell contact</subject><subject>gap junction</subject><subject>Humans</subject><subject>Mutation</subject><subject>Protein Processing, Post-Translational</subject><subject>Review</subject><subject>tight junction</subject><subject>Tight Junction Proteins - chemistry</subject><subject>Tight Junction Proteins - genetics</subject><subject>Tight Junction Proteins - metabolism</subject><issn>2168-8362</issn><issn>2168-8370</issn><issn>2168-8370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kU1vGyEQhlGVqonc_IRWHHtZh2FZYHuoEkVtPhS1l_bSC2L5iKnW4AJO5H_ftfyh5hIuzDDvvDPiQegDkDkQSS4ocClbQeaUAJ8DdIwzeIPOtu_NtnByjDk9Reel_CHTkZQTwd6hUyqAAaPiDP2-X0dTQ4p6xKucqgux4ORxXTg8jCnZZsg6RDzonIPLn_F394wnTXhc1DIFNWG_d8A6Wmw35ZC_R2-9Hos7398z9Ovb15_Xt83Dj5u766uHxjAuayNBa9oa2rdeWuclZbzV1gKBnhJDXDdQ2wndGTP4QegenPcd8HboGBDX8naGvux8V-th6axxsWY9qlUOS503KumgXlZiWKjH9KTY9DtMwGTwaW-Q09-1K1UtQzFuHHV0aV0UCClIz_tpxRnqdlKTUynZ-eMYIGqLRh3QqC0atUcz9X38f8dj1wHEJLjcCUL0KS_1c8qjVVVvxpR91tGEotrXZ_wDksufqg</recordid><startdate>20160102</startdate><enddate>20160102</enddate><creator>Stamatovic, Svetlana M</creator><creator>Johnson, Allison M</creator><creator>Keep, Richard F</creator><creator>Andjelkovic, Anuska V</creator><general>Taylor &amp; Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160102</creationdate><title>Junctional proteins of the blood-brain barrier: New insights into function and dysfunction</title><author>Stamatovic, Svetlana M ; Johnson, Allison M ; Keep, Richard F ; Andjelkovic, Anuska V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-81aa23c293f8def82463add101920c0e5b2d57a5ccbfb7a91eff5163b5410e363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>actin cytoskeleton</topic><topic>adherens junction</topic><topic>Animals</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>brain endothelial cells</topic><topic>Capillary Permeability</topic><topic>cell-cell contact</topic><topic>gap junction</topic><topic>Humans</topic><topic>Mutation</topic><topic>Protein Processing, Post-Translational</topic><topic>Review</topic><topic>tight junction</topic><topic>Tight Junction Proteins - chemistry</topic><topic>Tight Junction Proteins - genetics</topic><topic>Tight Junction Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stamatovic, Svetlana M</creatorcontrib><creatorcontrib>Johnson, Allison M</creatorcontrib><creatorcontrib>Keep, Richard F</creatorcontrib><creatorcontrib>Andjelkovic, Anuska V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Tissue barriers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stamatovic, Svetlana M</au><au>Johnson, Allison M</au><au>Keep, Richard F</au><au>Andjelkovic, Anuska V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Junctional proteins of the blood-brain barrier: New insights into function and dysfunction</atitle><jtitle>Tissue barriers</jtitle><addtitle>Tissue Barriers</addtitle><date>2016-01-02</date><risdate>2016</risdate><volume>4</volume><issue>1</issue><spage>e1154641</spage><epage>e1154641</epage><pages>e1154641-e1154641</pages><issn>2168-8362</issn><issn>2168-8370</issn><eissn>2168-8370</eissn><abstract>The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability. However, such alterations are also involved in remodeling the brain endothelial cell surface and regulating brain endothelial cell phenotype. This review summarizes the characteristics of brain endothelial tight, adherens and gap junctions and highlights structural and functional alterations in junctional proteins that may contribute to BBB dysfunction.</abstract><cop>United States</cop><pub>Taylor &amp; Francis</pub><pmid>27141427</pmid><doi>10.1080/21688370.2016.1154641</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2168-8362
ispartof Tissue barriers, 2016-01, Vol.4 (1), p.e1154641-e1154641
issn 2168-8362
2168-8370
2168-8370
language eng
recordid cdi_proquest_miscellaneous_1787096929
source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list); PubMed Central
subjects actin cytoskeleton
adherens junction
Animals
Blood-Brain Barrier - metabolism
brain endothelial cells
Capillary Permeability
cell-cell contact
gap junction
Humans
Mutation
Protein Processing, Post-Translational
Review
tight junction
Tight Junction Proteins - chemistry
Tight Junction Proteins - genetics
Tight Junction Proteins - metabolism
title Junctional proteins of the blood-brain barrier: New insights into function and dysfunction
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T17%3A27%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Junctional%20proteins%20of%20the%20blood-brain%20barrier:%20New%20insights%20into%20function%20and%20dysfunction&rft.jtitle=Tissue%20barriers&rft.au=Stamatovic,%20Svetlana%20M&rft.date=2016-01-02&rft.volume=4&rft.issue=1&rft.spage=e1154641&rft.epage=e1154641&rft.pages=e1154641-e1154641&rft.issn=2168-8362&rft.eissn=2168-8370&rft_id=info:doi/10.1080/21688370.2016.1154641&rft_dat=%3Cproquest_pubme%3E1787096929%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c468t-81aa23c293f8def82463add101920c0e5b2d57a5ccbfb7a91eff5163b5410e363%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1787096929&rft_id=info:pmid/27141427&rfr_iscdi=true