Severe bone marrow failure associated with the use of alternating steroid with chlorambucil in lupus membranous nephropathy in Chinese

Severe pancytopenia associated with the use of alternating steroid with chlorambucil regimen was described in six patients with nephrotic syndrome secondary to lupus membranous nephropathy (WHO class V). We believe this is the first report describing the life-threatening degree of marrow toxicity as...

Full description

Saved in:
Bibliographic Details
Published in:Lupus 2001-01, Vol.10 (4), p.295-298
Main Authors: Wang, A YM, Li, P KT, Lai, F MM, Chow, K M, Szeto, C C, Leung, C B, Lui, S F
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Agents, Alkylating - adverse effects
Antineoplastic Agents, Alkylating - therapeutic use
Bone marrow
Bone Marrow - drug effects
Bone Marrow - immunology
Bone Marrow Diseases - chemically induced
Bone Marrow Diseases - immunology
Bone Marrow Diseases - physiopathology
China
Chlorambucil - adverse effects
Chlorambucil - therapeutic use
Creatinine
Female
Hemoglobin
Humans
Kidney diseases
Leukopenia
Lupus
Lupus Nephritis - drug therapy
Lupus Nephritis - immunology
Lupus Nephritis - physiopathology
Male
Patients
Steroids
Steroids - adverse effects
Steroids - therapeutic use
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Severe pancytopenia associated with the use of alternating steroid with chlorambucil regimen was described in six patients with nephrotic syndrome secondary to lupus membranous nephropathy (WHO class V). We believe this is the first report describing the life-threatening degree of marrow toxicity associated with this regimen of alternating steroid with chlorambucil in a Chinese population. Our data suggests that the susceptibility to marrow toxicity with the use of chlorambucil may only be applicable to Chinese patients with underlying systemic lupus erythematosus as a similar degree of toxicity has neither been reported in lupus patients of other ethnic groups nor in non-lupus patients of Chinese origin.
ISSN:0961-2033
1477-0962
DOI:10.1191/096120301680416995