New lymphatic structures in colon cancer

Considering all these features these neo-generated organs deserve to be considered tertiary lymphatic structures.2,3 This process, observed independently from the presence of LN metastases, can be associated with intratumoral lymphocytic infiltration and it is generally considered as a tissue immune...

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Bibliographic Details
Published in:The American journal of surgery 2016-05, Vol.211 (5), p.974-974
Main Authors: Manenti, Antonio, M.D, Pavesi, Erica, M.D, Farinetti, Alberto, M.D, Reggiani Bonetti, Luca, M.D
Format: Article
Language:English
Subjects:
Biopsy, Needle
Colonic Neoplasms - pathology
Colorectal cancer
Female
Humans
Immunohistochemistry
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Lymphatic System - pathology
Male
Prognosis
Sensitivity and Specificity
Surgery
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Summary:Considering all these features these neo-generated organs deserve to be considered tertiary lymphatic structures.2,3 This process, observed independently from the presence of LN metastases, can be associated with intratumoral lymphocytic infiltration and it is generally considered as a tissue immune response to persistent antigenic stimuli.2-4 A corresponding neogenesis of lymphatic structures was observed in other cancers (breast, lung, skin melanoma, and so forth), and with minor number, also in inflammatory diseases of the colon.2 In our experience, based on histological examinations of surgical specimens, this immunological activity was demonstrated only in the regional lymphatic district. Because of its complexity, this topic requires further research; maybe tomorrow this colon cancer feature will be considered among the prognostic signs.5
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2015.10.011