Snake toxins that bind specifically to individual subtypes of muscarinic receptors

This paper discusses the properties of the three most specific ligands found for the extracellular faces of M 1, M 2 and M 4 muscarinic receptors (m1-toxin1, m2-toxin and m4-toxin, respectively). The primary goal of this paper is to show the known and potential usefulness of these toxins and their b...

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Bibliographic Details
Published in:Life sciences (1973) 2001-04, Vol.68 (22), p.2541-2547
Main Author: Potter, Lincoln T.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Binding Sites
Biotin
Elapid Venoms - chemistry
Elapid Venoms - metabolism
Elapid Venoms - pharmacology
Elapidae - metabolism
Humans
m1-Toxin1
m2-Toxin
m4-Toxin
Molecular Sequence Data
Muscarinic Antagonists - chemistry
Muscarinic Antagonists - metabolism
Muscarinic Antagonists - pharmacology
Neurotoxins - chemistry
Neurotoxins - metabolism
Neurotoxins - pharmacology
Protein Binding
Receptor, Muscarinic M1
Receptor, Muscarinic M2
Receptor, Muscarinic M4
Receptors, Muscarinic - metabolism
Sequence Alignment
Serpentes
Subtypes of muscarinic receptors
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Summary:This paper discusses the properties of the three most specific ligands found for the extracellular faces of M 1, M 2 and M 4 muscarinic receptors (m1-toxin1, m2-toxin and m4-toxin, respectively). The primary goal of this paper is to show the known and potential usefulness of these toxins and their biotinylated, radioactive, fluorescent and mutated derivatives.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(01)01050-5