IL-33 in T Cell Differentiation, Function, and Immune Homeostasis

Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4+ and CD8+ T cell activation and function, and have also revealed important distinctions. The IL-33 receptor ST2 is constitutively and abundantly expressed on T-helper-2 (Th2) and GATA-3+ regulatory T cells in a GATA-3-...

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Bibliographic Details
Published in:Trends in immunology 2016-05, Vol.37 (5), p.321-333
Main Authors: Peine, Michael, Marek, Roman M, Löhning, Max
Format: Article
Language:English
Subjects:
alarmin IL-33
Allergy and Immunology
Animals
Antigens
CD4+ and CD8+ T cell subsets
Cell Differentiation
Cytokines
Cytotoxicity
Feedback, Physiological
GATA3 Transcription Factor - metabolism
Gene expression
Gene Expression Regulation - immunology
Homeostasis
Humans
Interleukin-1 Receptor-Like 1 Protein - genetics
Interleukin-1 Receptor-Like 1 Protein - metabolism
Interleukin-33 - immunology
Lymphocyte Activation
Lymphocytes
Signal transduction
ST2/T1/IL-1RL1
STAT4/STAT5
T cell receptors
T-bet/GATA-3/Foxp3
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Regulatory - immunology
Th1/Th2/Treg/CTL
Transcription factors
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Summary:Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4+ and CD8+ T cell activation and function, and have also revealed important distinctions. The IL-33 receptor ST2 is constitutively and abundantly expressed on T-helper-2 (Th2) and GATA-3+ regulatory T cells in a GATA-3- and STAT5-dependent manner. Upon activation, Th1 and cytotoxic T cells express ST2 transiently, driven by T-bet and/or STAT4. We review these findings here, and critically examine evidence indicating that IL-33 enhances the differentiation and functionality of various T cell subsets through positive feedback loops involving lineage-specifying transcription factors. In this context, we discuss how quantitative and qualitative differences in ST2 expression between effector and GATA-3+ regulatory T cells may contribute to immune homeostasis, and outline important areas of future inquiry.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2016.03.007