Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia

Highlights • Rolipram improves cognition, reduces anxiety- and despair-like behaviors after BCCAO. • Rolipram decreases hippocampal neurodegeneration induced by BCCAO. • Rolipram increases DCX- and MAP-2 expression in the hippocampus of BCCAO mice.

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Bibliographic Details
Published in:Neuroscience 2016-06, Vol.326, p.69-83
Main Authors: Soares, Lígia Mendes, De Vry, Jochen, Steinbusch, Harry W.M, Milani, Humberto, Prickaerts, Jos, Weffort de Oliveira, Rúbia M
Format: Article
Language:English
Subjects:
Animals
Anxiety - etiology
Anxiety - prevention & control
Behavior, Animal - drug effects
bilateral common carotid artery occlusion
Brain Ischemia - complications
Brain Ischemia - metabolism
Cognitive Dysfunction - etiology
Cognitive Dysfunction - prevention & control
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - pathology
Male
Mice
Mice, Inbred C57BL
Microtubule-Associated Proteins - metabolism
Neurology
Neuronal Plasticity - drug effects
Neuropeptides - metabolism
neuroprotection
Phosphodiesterase 4 Inhibitors - administration & dosage
rolipram
Rolipram - administration & dosage
Spatial Memory - drug effects
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Description
Summary:Highlights • Rolipram improves cognition, reduces anxiety- and despair-like behaviors after BCCAO. • Rolipram decreases hippocampal neurodegeneration induced by BCCAO. • Rolipram increases DCX- and MAP-2 expression in the hippocampus of BCCAO mice.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.03.062