IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation

Highlights • hIL-1Ra-Fc exerted therapeutic effect by the reciprocal regulation of Th17/Treg balance in rheumatoid arthritis. • hIL-1Ra-Fc inhibited osteoclastogenesis and angiogenesis at affected joints of murine model.

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Bibliographic Details
Published in:Immunology letters 2016-04, Vol.172, p.56-66
Main Authors: Lee, Seon-Yeong, Min, Hong Ki, Lee, Seung Hoon, Kwok, Seung-Ki, Ju, Ji Hyeon, Cho, Mi-La, Park, Sung-Hwan
Format: Article
Language:English
Subjects:
Allergy and Immunology
Angiogenesis
Animals
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - therapy
Autoimmune arthritis
Cytokines - metabolism
Disease Models, Animal
Female
Humans
IL-1 receptor antagonist
Immunoglobulin Fc Fragments - genetics
Immunotherapy - methods
Interleukin 1 Receptor Antagonist Protein - genetics
Interleukin 1 Receptor Antagonist Protein - therapeutic use
Male
Mice
Mice, Inbred DBA
Middle Aged
Osteoclastogenesis
Protein Engineering
Recombinant Proteins - genetics
Regulatory T cells
Signal Transduction
T-Lymphocytes, Regulatory - immunology
Th17 cells
Th17 Cells - immunology
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Description
Summary:Highlights • hIL-1Ra-Fc exerted therapeutic effect by the reciprocal regulation of Th17/Treg balance in rheumatoid arthritis. • hIL-1Ra-Fc inhibited osteoclastogenesis and angiogenesis at affected joints of murine model.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.02.011