Hemorrhagic Transformation of Scrub Typhus Encephalitis: A Rare Entity

Central nervous system (CNS) involvement of scrub typhus infection is well known. Most CNS involvement of scrub typhus infection present as meningitis or encephalitis. We report on a patient suffering from hemorrhagic transformation of intracranial lesions caused by Orientia tsutsugamushi . A 53-yea...

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Bibliographic Details
Published in:Clinical neuroradiology (Munich) 2015-12, Vol.25 (4), p.415-418
Main Authors: Kim, H.-C., Yoon, K.-W., Yoo, D.-S., Cho, C.-S.
Format: Article
Language:English
Subjects:
Cerebral Hemorrhage - diagnosis
Cerebral Hemorrhage - etiology
Cerebral Hemorrhage - therapy
Correspondence
Diagnosis, Differential
Encephalitis
Fatal Outcome
Female
Health aspects
Humans
Infections
Infectious Encephalitis - complications
Infectious Encephalitis - diagnosis
Infectious Encephalitis - therapy
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Meningitis
Middle Aged
Neurology
Neuroradiology
Neurosurgery
Orientia tsutsugamushi
Rare Diseases - diagnosis
Rare Diseases - etiology
Rare Diseases - therapy
Scrub typhus
Scrub Typhus - complications
Scrub Typhus - diagnosis
Scrub Typhus - therapy
Tetracycline
Tetracyclines
Tomography, X-Ray Computed - methods
Typhus
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Description
Summary:Central nervous system (CNS) involvement of scrub typhus infection is well known. Most CNS involvement of scrub typhus infection present as meningitis or encephalitis. We report on a patient suffering from hemorrhagic transformation of intracranial lesions caused by Orientia tsutsugamushi . A 53-year-old female farmer who was infected by scrub typhus was treated with doxycycline and recovered from the systemic illness. However, headache persisted. Brain radiologic studies revealed acute intracranial hemorrhage and enhancing lesion, which implied a CNS involvement. Hemorrhagic transformation of encephalitis by scrub typhus is very rare complication and to our best knowledge, this is the first report of hemorrhagic transformation of scrub typhus encephalitis. Clinician should consider the possibility of hemorrhagic transformation of encephalitis in cases of scrub typhus infection.
ISSN:1869-1439
1869-1447
DOI:10.1007/s00062-014-0348-9