Immunogenicity and safety of two doses of catch-up immunization with Haemophilus influenzae type b conjugate vaccine in Indian children living with HIV

• Published in: Vaccine 2016-04, Vol.34 (19), p.2267-2274
• Main Authors: Arya, Bikas K, Bhattacharya, Sangeeta Das, Sutcliffe, Catherine G, Saha, Malay K, Bhattacharyya, Subhasish, Niyogi, Swapan Kumar, Moss, William J, Panda, Samiran, Das, Ranjan Saurav, Mallick, Mausom, Mandal, Sutapa
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Allergy and Immunology; Anti-Hib PRP IgG; Antibodies, Bacterial - blood; Antiretroviral agents; Antiretroviral drugs; Bacterial Capsules - immunology; Binding sites; Child; Child, Preschool; Colonization; Conjugate vaccines; Disease; Families & family life; Female; Haemophilus Infections - prevention & control; Haemophilus influenzae; Haemophilus influenzae type b; Haemophilus Vaccines - administration & dosage; Haemophilus Vaccines - immunology; Haemophilus Vaccines - therapeutic use; Health risks; HIV; HIV Infections; Human immunodeficiency virus; Humans; Immune response; Immunization; Immunization Schedule; Immunization, Secondary; Immunogenicity; Immunoglobulin G - blood; India; Infant; Laboratories; Male; Nasopharyngeal carriage; Prophylaxis; Prospective Studies; Regression analysis; Vaccines; Vaccines, Conjugate - administration & dosage; Vaccines, Conjugate - immunology; Vaccines, Conjugate - therapeutic use; Viral Load
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.03.012

Highlights • The optimal schedule for HibCV in children with HIV is unclear in settings with limited access to ART. • The recommended schedule of 1 dose of HibCV may be inadequate in such settings. • 76% of HIV infected children 2–15 years mounted an immune response following 2-doses of HibCV. • Immune responses were adequate even among children with viral loads >100,000 copies/mL. • Anti-Hib-PRP IgG ≥ 3.3 μg/mL provided protection against Hib NP colonization in children with HIV.