Cloning of the promoter of NDE1 , a gene implicated in psychiatric and neurodevelopmental disorders through copy number variation

Highlights • The complex promoter system of the neurodevelopmental gene NDE1 is cloned. • This gene is implicated in major mental illness through copy number variation. • In neuroblastoma cells, one NDE1 transcript is predominantly expressed. • The importance of the 5′ UTR of this transcript is dete...

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Bibliographic Details
Published in:Neuroscience 2016-06, Vol.324, p.262-270
Main Author: Bradshaw, N.J
Format: Article
Language:English
Subjects:
alternate splicing
Alternative Splicing
Base Sequence
Cell Line, Tumor
chromosome 16p13.11 duplication
Cloning, Molecular - methods
copy number variation (CNV)
DNA Copy Number Variations
HEK293 Cells
Humans
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - metabolism
Neurology
Nuclear Distribution Element 1 (NDE1)
promoter characterization
Promoter Regions, Genetic
schizophrenia
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Summary:Highlights • The complex promoter system of the neurodevelopmental gene NDE1 is cloned. • This gene is implicated in major mental illness through copy number variation. • In neuroblastoma cells, one NDE1 transcript is predominantly expressed. • The importance of the 5′ UTR of this transcript is determined. • These will facilitate the study of NDE1 duplication in major mental illness.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.03.018