Detection and expression of Epstein-Barr Virus (EBV) DNA in tissues from penile tumors in Brazil

Epstein-Barr Virus (EBV) is prevalent in all human populations and high titers of antibody correlate with specific malignancies such as Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease. Our study detected EBV DNA in 20 of 21 penile tumor samples using PCR reaction. Expre...

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Bibliographic Details
Published in:Cancer letters 2004-11, Vol.215 (1), p.79-82
Main Authors: Alves, Gilda, Menezes Trindade Macrini, Camila, de Souza Nascimento, Patrícia, Carlos Morais, José, Augusto Ornellas, Antonio
Format: Article
Language:English
Subjects:
Bacterial infections
Brazil - epidemiology
Cancer
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - virology
Carcinoma, Verrucous - epidemiology
Carcinoma, Verrucous - metabolism
Carcinoma, Verrucous - virology
Deoxyribonucleic acid
DNA
DNA, Viral - genetics
DNA, Viral - metabolism
EBV
Epstein-Barr virus
Epstein-Barr Virus Infections - epidemiology
Epstein-Barr Virus Infections - genetics
Epstein-Barr Virus Infections - virology
Genes
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - isolation & purification
Humans
LMP-1
Lymphocytes
Lymphoma
Male
Neoplasm Invasiveness - pathology
Patients
Penile Neoplasms - epidemiology
Penile Neoplasms - genetics
Penile Neoplasms - virology
Penile tumor
Polymerase Chain Reaction
Thermal cycling
Tumors
Viral infections
Viral Matrix Proteins - genetics
Viral Matrix Proteins - metabolism
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Summary:Epstein-Barr Virus (EBV) is prevalent in all human populations and high titers of antibody correlate with specific malignancies such as Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease. Our study detected EBV DNA in 20 of 21 penile tumor samples using PCR reaction. Expression of EBV protein LMP-1 was identified in tumor cells from two EBV PCR-positive tumors. Our findings indicate that EBV can be implicated in rising and/or progression of penile tumors independently of the histological type.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.04.025