Enhanced Cellular Uptake of Bowl-like Microcapsules

Among several properties of colloidal particles, shape is emerging as an important parameter for tailoring the interactions between particles and cells. In this study, bowl-like multilayer microcapsules were prepared by osmotic-induced invagination of their spherical counterparts in a concentrated p...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2016-05, Vol.8 (18), p.11210-11214
Main Authors: Li, Huiying, Zhang, Wenbo, Tong, Weijun, Gao, Changyou
Format: Article
Language:English
Subjects:
Capsules - chemistry
Osmosis
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Summary:Among several properties of colloidal particles, shape is emerging as an important parameter for tailoring the interactions between particles and cells. In this study, bowl-like multilayer microcapsules were prepared by osmotic-induced invagination of their spherical counterparts in a concentrated polyelectrolyte solution. The internalization behaviors of bowl-like and spherical microcapsules were compared by coincubation with smooth muscle cells (SMCs) and macrophages. The bowl-like capsules tended to attach onto the cell membranes from the bend side and could be enwrapped by the membranes of SMCs, leading to a faster uptake rate and larger accumulation inside cells than those of their spherical counterparts. These results are important for understanding the shape-dependent internalization behavior, providing useful guidance for further materials design especially in biomedical applications.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.6b02965