Screening and validation of long non-coding RNAs in brain tissue of inflammation-induced preterm mice

To investigate the association between long non-coding RNAs (lncRNAs) and brain injury in inflammation-induced preterm mice, and to provide a reference for the prevention and treatment of brain injury. An intraperitoneal injection of lipopolysaccharide in pregnant mice was performed to establish a m...

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Bibliographic Details
Published in:Zhongguo dang dai er ke za zhi 2016-05, Vol.18 (5), p.435-439
Main Authors: Chen, Ru-Juan, Xi, Sha, Wang, Fan, Xiao, Mi, Lin, Xiao-Jie, Liu, Li
Format: Article
Language:Chinese
Subjects:
Animals
Brain - metabolism
Female
Inflammation - complications
Inflammation - metabolism
Mice
Mice, Inbred BALB C
Receptors, G-Protein-Coupled - physiology
RNA, Long Noncoding - analysis
Signal Transduction - physiology
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Summary:To investigate the association between long non-coding RNAs (lncRNAs) and brain injury in inflammation-induced preterm mice, and to provide a reference for the prevention and treatment of brain injury. An intraperitoneal injection of lipopolysaccharide in pregnant mice was performed to establish a model of inflammation-induced preterm mice with brain injury (preterm group). The full-term mice delivered by normal pregnant mice were used as controls (full-term group). The lncRNA chip assay was used to screen out the lncRNAs associated with brain injury in preterm mice. Quantitative real-time PCR was used to validate the lncRNAs identified by the above method. The preterm and full-term groups showed significant differences in the expression of 1 978 lncRNAs (P
ISSN:1008-8830
DOI:10.7499/j.issn.1008-8830.2016.05.012