Management of central giant cell granuloma of the jaws with intralesional steroid injection and review of the literature

• Published in: Oral and maxillofacial surgery 2016-06, Vol.20 (2), p.203-209
• Main Authors: Dolanmaz, Doğan, Esen, Alparslan, Mihmanlı, Ahmet, Işık, Kubilay
• Format: Article
• Language: English
• Subjects: Adrenal Cortex Hormones - administration & dosage; Bupivacaine - administration & dosage; Case Report; Dentistry; Drug Administration Schedule; Drug Combinations; Epinephrine - administration & dosage; Granuloma, Giant Cell - drug therapy; Humans; Injections, Intralesional; Jaw Diseases - drug therapy; Medicine; Medicine & Public Health; Oral and Maxillofacial Surgery; Retreatment; Treatment Outcome; Triamcinolone Acetonide - administration & dosage
• ISSN: 1865-1550; 1865-1569
• DOI: 10.1007/s10006-015-0530-5

Purpose We report the results of the intralesional steroid injections for the management of central giant cell granuloma (CGCG) of the jaws. Methods Seven CGCGs were treated with intralesional injection of corticosteroids. To accomplish this, 3.5 mL of triamcinolone and 3.5 mL of 0.5 % marcaine with 1/200,000 epinephrine (total 7 mL) were mixed. An adequate amount of steroid was injected into different areas of the lesion. This procedure was repeated on a weekly basis for 6 weeks. Results Clinical and radiological examination showed complete resolution and ossification of the lesions in four patients. Partial recovery was achieved in two patients. One patient did not respond to the treatment and underwent surgical curettage. Conclusions We suggest that intralesional steroid injection is safe and effective for the treatment of CGCG, especially in non-aggressive lesions.