Modeling the impact of imperfect HIV vaccines on the incidence of the infection

One concern about HIV vaccine trials is that participants might develop a false sense of security and increase their risk behavior. This fear has (at least partially) impaired the development of extensive clinical trials on HIV vaccines and are, in principle, justified. In this paper, we develop a d...

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Bibliographic Details
Published in:Mathematical and computer modelling 2001-08, Vol.34 (3), p.345-351
Main Authors: Massad, E., Coutinho, F.A.B., Burattini, M.N., Lopez, L.F., Struchiner, C.J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Control strategies
Fundamental and applied biological sciences. Psychology
General aspects
HIV
Human immunodeficiency virus
Mathematical modeling
Transmission dynamics
Vaccines
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:One concern about HIV vaccine trials is that participants might develop a false sense of security and increase their risk behavior. This fear has (at least partially) impaired the development of extensive clinical trials on HIV vaccines and are, in principle, justified. In this paper, we develop a dynamical model which allows experiments on the effects of an imperfect vaccine on a population prone to change its risk behavior. Our results show that even the poorest of the candidate vaccines to be seriously considered, may have beneficial effects on reducing transmission, even when risk behaviors increases.
ISSN:0895-7177
1872-9479
DOI:10.1016/S0895-7177(01)00066-8