Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus

The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-03, Vol.303 (5665), p.1866-1870
Main Authors: Stevens, James, Corper, Adam L., Basler, Christopher F., Taubenberger, Jeffery K., Palese, Peter, Wilson, Ian A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Binding Sites
Biological and medical sciences
Carbohydrate Conformation
Cloning, Molecular
Communicable Diseases
Crystal structure
Crystalline structure
Crystallography, X-Ray
Fundamental and applied biological sciences. Psychology
Genes
Glycosylation
Hemagglutinin Glycoproteins, Influenza Virus - chemistry
Hemagglutinin Glycoproteins, Influenza Virus - metabolism
Histidine - chemistry
Histidine - metabolism
History
History, 20th Century
Humans
Hydrogen Bonding
Infections
Influenza
Influenza A virus - classification
Influenza A virus - immunology
Influenza A virus - pathogenicity
Influenza virus
Influenza, Human - epidemiology
Influenza, Human - history
Influenza, Human - virology
Molecular biophysics
Molecular Sequence Data
Monomers
Orthomyxoviridae
Pandemics
Protein Conformation
Protein Structure, Quaternary
Protein Structure, Secondary
Protein Structure, Tertiary
Receptors
Receptors, Virus - metabolism
Sialic Acids - metabolism
Structure in molecular biology
Swine
Trimers
Viruses
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Summary:The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin gene from viral RNA fragments preserved in 1918 formalin-fixed lung tissues. A narrow avian-like receptor-binding site, two previously unobserved histidine patches, and a less exposed surface loop at the cleavage site that activates viral membrane fusion reveal structural features primarily found in avian viruses, which may have contributed to the extraordinarily high infectivity and mortality rates observed during 1918.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1093373