Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

Retinoids are a group of substances comprising vitamin A and its natural and synthetic derivatives. Retinoids were first used in dermatology in 1943 by Straumfjord for acne vulgaris. Since that time, retinoids have been utilized in the management and treatment of various skin conditions, including p...

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Bibliographic Details
Published in:American journal of clinical dermatology 2016-06, Vol.17 (3), p.265-276
Main Authors: Riahi, Ryan R., Bush, Amelia E., Cohen, Philip R.
Format: Article
Language:English
Subjects:
Acne Vulgaris - drug therapy
Administration, Cutaneous
Alopecia Areata - drug therapy
Collagen - metabolism
Collagen - radiation effects
Dermatology
Free Radicals - metabolism
Free Radicals - radiation effects
Hand-Foot Syndrome - drug therapy
Humans
Medicine
Medicine & Public Health
Metalloproteases - metabolism
Metalloproteases - radiation effects
Pharmacology/Toxicology
Pharmacotherapy
Retinoids - pharmacology
Retinoids - therapeutic use
Review Article
Skin - metabolism
Skin - pathology
Skin - radiation effects
Skin Aging - drug effects
Skin Aging - pathology
Skin Aging - radiation effects
Ultraviolet Rays - adverse effects
Vitamin A - metabolism
Vitamin A - therapeutic use
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Summary:Retinoids are a group of substances comprising vitamin A and its natural and synthetic derivatives. Retinoids were first used in dermatology in 1943 by Straumfjord for acne vulgaris. Since that time, retinoids have been utilized in the management and treatment of various skin conditions, including photoaging. Photodamage of the skin occurs as a consequence of cumulative exposure to solar ultraviolet radiation (UVR) and is characterized by deep wrinkles, easy bruising, inelasticity, mottled pigmentation, roughness, and telangiectasias. The mechanism of UVR-induced photodamage is multifactorial. Retinoids have demonstrated efficacy in the treatment of photoaged skin. Indeed, understanding the pathophysiology of photoaging and the molecular mechanism of retinoids can not only provide insight into the effects retinoids can exert in treating photoaging but also provide the rationale for their use in the treatment of other dermatologic diseases.
ISSN:1175-0561
1179-1888
DOI:10.1007/s40257-016-0185-5