Reliability of immunocytochemistry and fluorescence in situ hybridization on fine-needle aspiration cytology samples of breast cancers: A comparative study

Introduction To characterize breast tumors and metastases, fine‐needle aspiration cytology (FNAB) can be a favorable first choice. However, the diagnostic accuracy of ancillary tests applied to FNAB samples is yet to be validated. Patients and Methods We examined 110 breast cancer patients' pai...

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Published in:Diagnostic cytopathology 2016-06, Vol.44 (6), p.466-471
Main Authors: Acs, Balazs, Szekely, Nora, Szasz, Attila Marcell, Lotz, Gabor, Szekely, Tamas, Istok, Roland, Szekely, Eszter, Madaras, Lilla, Kulka, Janina, Jaray, Balazs
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Biopsy, Fine-Needle
breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
cytology
Female
fine-needle aspiration biopsy
fluorescence in situ hybridization
Humans
immunocytochemistry
Immunohistochemistry
In Situ Hybridization, Fluorescence
Receptor, ErbB-2 - genetics
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Reproducibility of Results
Sensitivity and Specificity
surgical resection specimen
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Summary:Introduction To characterize breast tumors and metastases, fine‐needle aspiration cytology (FNAB) can be a favorable first choice. However, the diagnostic accuracy of ancillary tests applied to FNAB samples is yet to be validated. Patients and Methods We examined 110 breast cancer patients' paired cytological and surgical resection specimens evaluated between 2005 and 2014. Comparison of ER and Her2 immunocytochemical (ICC) and immunohistochemical (IHC) staining and HER2 fluorescence in situ hybridization (FISH) was performed. Results Significant difference (p 
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23463