Cytotoxic Aporphines from Artabotrys Crassifolius

Artabotrys crassifolius Hook. f. & Thomson is a medicinal plant used in Malaysia. The cytotoxic effects of the hexane, chloroform and ethanol extracts of the leaves and bark were examined in vitro against MCF-7, MDA-468 and HCT-116 cells. The chloroform extract of the bark inhibited the growth o...

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Bibliographic Details
Published in:Natural Product Communications 2016-03, Vol.11 (3), p.389-392
Main Authors: Kwan, Tan Kok, Shipton, Fiona, Azman, Nadiah Syafiqah Nor, Hossan, Shahadat, Jin, Khoo Ten, Wiart, Christophe
Format: Article
Language:English
Subjects:
Annonaceae - chemistry
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
Humans
Models, Molecular
Molecular Structure
Plant Bark - chemistry
Plant Leaves - chemistry
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Summary:Artabotrys crassifolius Hook. f. & Thomson is a medicinal plant used in Malaysia. The cytotoxic effects of the hexane, chloroform and ethanol extracts of the leaves and bark were examined in vitro against MCF-7, MDA-468 and HCT-116 cells. The chloroform extract of the bark inhibited the growth of all cell lines with GI50 values ranging from 4.2 μg/mL to 9.4 μg/mL. Silica gel column chromatography of this extract yielded artabotrine, liridine, atherospermidine and lysicamine. Artabotrine and lysicamine inhibited the growth of HCT-116 and MCF-7 cells with GI50 values ranging from 3.3 μM to 3.9 μM. These alkaloids were not toxic to human embryonic kidney cells (HEK297) up to a concentration of 50 μg/mL.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1601100317