Non-epithelial tumors of the larynx: a single institution review

Abstract Aim Non-epithelial tumors of the larynx and rare and encompass a wide range of pathology. We present the decade-long experience of a single institution to define clinical presentations and outcomes. Material and Methods Ten year retrospective chart review of a tertiary head and neck cancer...

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Bibliographic Details
Published in:American journal of otolaryngology 2016-05, Vol.37 (3), p.279-285
Main Authors: Karatayli-Ozgursoy, S, Bishop, J.A, Hillel, A.T, Akst, L.M, Best, S.R., MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Airway management
Biopsy
Carcinoma - mortality
Carcinoma - pathology
Carcinoma - therapy
Chemotherapy
Child
Child, Preschool
Combined Modality Therapy
Endoscopy
Female
Histology
Humans
Infant
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - therapy
Laryngectomy
Larynx
Lymphocytes
Male
Melanoma
Metastasis
Middle Aged
Ostomy
Otolaryngology
Pathology
Retrospective Studies
Skin cancer
Surgery
Thyroid gland
Treatment Outcome
Tumors
Young Adult
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Summary:Abstract Aim Non-epithelial tumors of the larynx and rare and encompass a wide range of pathology. We present the decade-long experience of a single institution to define clinical presentations and outcomes. Material and Methods Ten year retrospective chart review of a tertiary head and neck cancer center. Index patients were identified from a review of a pathology database, and patient demographics, presenting signs and symptoms, treatment modalities, and clinical outcomes were extracted from electronic medical records. Epithelial tumors (squamous cell carcinoma, spindle cell carcinoma, and salivary tumors), granulomas, sarcoidosis, papilloma, and amyloidosis were all excluded. Results Twenty-four patients with ages ranging from 2 months-old to 84 years were identified. Malignant lesions (11) included chondrosarcoma (6), Kaposi’s sarcoma (2), metastatic melanoma, synovial cell sarcoma, and T cell neoplasm. Six were operated upon endolaryngeally, but four required either upfront or salvage total laryngectomy. Two received adjuvant therapy. Benign lesions (13) included hemangioma (4), granular cell tumor (3), myofibroblastic tumor (2), schwannoma (2), chondroma, and ossifying fibromyxoid tumor. Nine underwent endolaryngeal operations, and four were managed medically or with observation. None have required aggressive open resection or total laryngectomy. Conclusion Treatment approach of non-epithelial tumors of the larynx depends on the site and extent of the tumor, histology, and sensitivity of adjuvant therapy. Benign tumors can be managed without need for aggressive resection thereby sparing laryngeal function.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2016.01.005